πŸ›οΈ Verified NIH Record β€’ Updated 2026-05-05

A Study of ZW191 in Participants With Solid Tumors (NCT06555744)

A Phase 1, Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of Ascending Doses of a Folate Receptor Alpha Antibody Drug Conjugate, ZW191, in Participants With Advanced Solid Tumors

πŸ”΅ Active, Not Recruiting Phase1 πŸ’Š Investigational Drug / Biologic Sponsor: Zymeworks BC Inc.

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to find out if ZW191 is safe and can treat participants with advanced cancers, including ovarian, endometrial, and non-small cell lung cancers.

Who can join: Review the eligibility criteria below.

Location: Yale University β€” New Haven, Connecticut

Age range: 18 Years

πŸ§ͺ Interventions in This Study

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (27 Sites)

Showing the first 25 of 27 sites.

  • Yale University β€” New Haven, Connecticut
  • The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute β€” Columbus, Ohio
  • Stephenson Cancer Center β€” Oklahoma City, Oklahoma
  • NEXT Oncology β€” San Antonio, Texas
  • NEXT Virginia β€” Fairfax, Virginia
  • Linear Clinical Research β€” Nedlands,
  • Royal North Shore Hospital Northern Sydney Cancer Centre β€” St Leonards,
  • National Cancer Center Hospital East β€” Kashiwa-shi,
  • Saitama Medical University International Medical Center β€” Saitama,
  • National Cancer Center Hospital β€” Tokyo,
  • The Cancer Institute Hospital of JFCR β€” Tokyo,
  • National University Health System (NUHS) - National University Cancer Institute Singapore (NCIS) β€” Singapore,
  • National Cancer Centre Singapore β€” Singapore,
  • Curie Oncology β€” Singapore,
  • National Cancer Center β€” Goyang-si,
  • Seoul National University Bundang Hospital β€” Seongnam-si,
  • Seoul National University Hospital β€” Seoul,
  • Severance Hospital, Yonsei University Health System β€” Seoul,
  • Asan Medical Center β€” Seoul,
  • Samsung Medical Center β€” Seoul,
  • Gangnam Severance Hospital β€” Seoul,
  • Hospital Universitari Vall d'Hebron β€” Barcelona,
  • Hospital Universitario Reina Sofia β€” CΓ³rdoba,
  • ClΓ­nica Universidad de Navarra β€” Madrid,
  • NEXT Oncology Madrid β€” Madrid,

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—