A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK (NCT06556368)
A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Three-arm Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tarcocimab Tedromer and Tabirafusp Tedromer Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)
🩺 Plain-English Summary (8th-Grade Level)
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants with Neovascular (Wet) Age-related Macular Degeneration (wAMD)
Who can join: Review the eligibility criteria below.
Location: Associated Retina Consultants — Gilbert, Arizona
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (72 Sites)
Showing the first 25 of 72 sites.
- Associated Retina Consultants — Gilbert, Arizona
- Associated Retina Consultants — Phoenix, Arizona
- Retina Macula Institute of Arizona — Scottsdale, Arizona
- Retina Associates SW — Tucson, Arizona
- Retina Consultants of Orange County — Fullerton, California
- Global Research Management, Inc. - Lugene Eye Institute — Glendale, California
- Retinal Consultants Medical Group, Inc. — Modesto, California
- California Eye Specialists Medical Group, Inc. — Pasadena, California
- California Eye Specialists Medical Group, Inc. — Redlands, California
- Retinal Consultants Medical Group Inc — Sacramento, California
- Retina Consultants of Southern Colorado — Colorado Springs, Colorado
- Retina Group of New England, PC — Waterford, Connecticut
- Blue Ocean Clinical Research — Clearwater, Florida
- Retina Group of Florida — Fort Lauderdale, Florida
- National Ophthalmic Research Institute — Fort Myers, Florida
- Retina Group of Florida — Sarasota, Florida
- Center for Retina and Macular Disease — Winter Haven, Florida
- Southeast Retina Center — Augusta, Georgia
- Retina Associates, Ltd — Elmhurst, Illinois
- Illinois Retina Associates — Oak Park, Illinois
- Associated Vitreoretinal and Uveitis Consultants LLC — Carmel, Indiana
- Midwest Eye Institute — Carmel, Indiana
- The Retina Care Center — Baltimore, Maryland
- Cumberland Valley Retina Consultants — Hagerstown, Maryland
- Ophthalmic Consultants of Boston — Boston, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Wet Age-related Macular Degeneration
- Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT] — Bakersfield, California
Explore by condition: All Wet Age-related Macular Degeneration clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.