A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis (NCT06558279)
A Randomized, Double-Blinded, Placebo-Controlled, Phase 3, Parallel-Group Design Study Evaluating the Efficacy and Safety of Efgartigimod PH20 SC Administered by Prefilled Syringe in Adult Participants With Ocular Myasthenia Gravis
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy and safety of efgartigimod PH20 SC given by a pre-filled syringe in adult patients with ocular myasthenia gravis. The study consists of a part A (approximately 7 weeks) and a part B (up to 2 years). In part A, half of the participants will receive efgartigimod PH20 SC and the other half will receive placebo. In part B, all participants will receive efgartigimod PH20 SC. The participants will be in the study for about up to 2 years and 12 weeks.
Who can join: Review the eligibility criteria below.
Location: HonorHealth Neurology - Bob Bové Neuroscience Institute — Scottsdale, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (102 Sites)
Showing the first 25 of 102 sites.
- HonorHealth Neurology - Bob Bové Neuroscience Institute — Scottsdale, Arizona
- Loma Linda University Health — Loma Linda, California
- USC Roski Eye Institute - Los Angeles — Los Angeles, California
- University of California San Francisco — San Francisco, California
- Neurology Offices of South Florida — Boca Raton, Florida
- SFM Clinical Research, LLC — Boca Raton, Florida
- Neurology Associates PA — Maitland, Florida
- University of South Florida — Tampa, Florida
- Northwestern Memorial Hospital — Chicago, Illinois
- University of California Irvine — Columbia, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Henry Ford Health System — Detroit, Michigan
- Robert Wood Johnson Medical School — New Brunswick, New Jersey
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina
- Duke Neurological Disorders Clinic — Durham, North Carolina
- Cleveland Clinic — Cleveland, Ohio
- Martha Morehouse Medical plaza — Columbus, Ohio
- Penn Medicine University City — Philadelphia, Pennsylvania
- National Neuromuscular Research Institute — Austin, Texas
- Houston Methodist Neurological Institute — Houston, Texas
- Box Hill Hospital — Box Hill,
- The Alfred Hospital — Melbourne,
- Gold Coast University Hospital — Southport,
- Universitätsklinikum AKH Wien — Vienna,
- UZ Leuven — Leuven,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Myasthenia Gravis, Ocular clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.