THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension (NCT06559891)
A Pivotal, Prospective, Multicenter, 2:1 Randomized, Double Blind, Controlled, Study Comparing the THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension (The THRIVE Study)
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of the THRIVE Pivotal study is to demonstrate the adjunctive effectiveness and the safety of the TIVUS system in: 1. subjects with uncontrolled hypertension (HTN) receiving 0 - 2 anti-hypertensive drugs of different classes in whom the anti-hypertensive medications will be stopped for a 4-week wash-out period before RDN/Sham procedure and during 2 months after procedure. 2. subjects with controlled hypertension receiving 1 - 2 anti-hypertensive drugs of different classes and who accept to be off-medications for a 4-week wash-out period before RDN/Sham procedure and 2 months after the procedure
Who can join: Review the eligibility criteria below.
Location: Cardiology, PC — Birmingham, Alabama
Age range: 22 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (50 Sites)
Showing the first 25 of 50 sites.
- Cardiology, PC — Birmingham, Alabama
- HonorHealth — Scottsdale, Arizona
- St. Bernard's Medical Center — Jonesboro, Arkansas
- Arkansas Heart Hospital — Little Rock, Arkansas
- Cedar-Sinai Medical Center — Los Angeles, California
- Stanford University — Palo Alto, California
- Connecticut Clinical Research, LLC (Bridgeport) — Bridgeport, Connecticut
- Ascension- Sacred Heart — Pensecola, Florida
- University of South Florida — Tampa, Florida
- Ascension Alexian Brothers — Elk Grove Village, Illinois
- St. John's Prairie Heart — Springfield, Illinois
- Southern Illinois University, School of Medicine — Springfield, Illinois
- Cardiovascular Institute of the South — Houma, Louisiana
- Ochsner Medical Center — New Orleans, Louisiana
- Henry Ford Hospital — Detroit, Michigan
- Henry Ford Providence Hospital — Southfield, Michigan
- Gulfport Memorial Hospital — Gulfport, Mississippi
- Jackson Heart Clinic — Jackson, Mississippi
- St Lukes Hospital — Kansas City, Missouri
- Renown Regional Medical Center — Reno, Nevada
- Virtua Health — Camden, New Jersey
- Jersey Shore University Medical Center — Neptune City, New Jersey
- St. Joseph — Liverpool, New York
- Nyph/Cumc — New York, New York
- NC Heart and Vascular — Raleigh, North Carolina
📞 Contact the Study Coordinator
Phone: (651) 324-4931
Email: lisa.melchior@bsci.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hypertension
- Implementing a Home Blood Pressure Monitoring Program in Primary Care — New York, New York
- SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN — Birmingham, Alabama
- Stress and Blood Pressure Management for Caregivers — Columbus, Ohio
- Caveolin-1 and Vascular Dysfunction — Boston, Massachusetts
- The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension — Birmingham, Alabama
- Skills-Based Educational Strategies for Reduction of Vascular Events in Orange County — Irvine, California
Explore by condition: All Hypertension clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.