🏛️ Verified NIH Record • Updated 2026-05-14
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN) (NCT06564142)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Povetacicept in Adults With Immunoglobulin A Nephropathy (RAINIER)
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Alpine Immune Sciences Inc, A Subsidiary of Vertex
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the efficacy of povetacicept in adult participants compared with placebo in reducing proteinuria and preserving renal function.
Who can join: Review the eligibility criteria below.
Location: Apogee Clinical Research, LLC — Huntsville, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (318 Sites)
Showing the first 25 of 318 sites.
- Apogee Clinical Research, LLC — Huntsville, Alabama
- Arizona Kidney Disease and Hypertension Center - Thomas Office — Phoenix, Arizona
- Arizona Kidney Disease and Hypertension Center - Tuscon — Tucson, Arizona
- West Coast Kidney — Fremont, California
- The Medical Research Group, Inc. (FRENOVA) — Fresno, California
- CARE Institute - Carabello Kidney — Los Angeles, California
- Providence Medical Foundation - Orange — Orange, California
- National Nephrology Alliance Research — Riverside, California
- UC Davis Health — Sacramento, California
- Zuckerberg San Francisco General Hospital and Trauma Center — San Francisco, California
- University of California San Francisco (UCSF) — San Francisco, California
- Western Nephrology — Arvada, Colorado
- Colorado Kidney Care — Denver, Colorado
- Nephrology Associates Delaware Kidney (FRENOVA) — Newark, Delaware
- South Florida Nephrology Group PA, Research Div. — Coral Springs, Florida
- Dolphin Medical Research — Doral, Florida
- Nephrology Associates of Central Florida — Hollywood, Florida
- Tectum Medical Research, LLC — Hollywood, Florida
- South Florida Research Institute — Lauderdale Lakes, Florida
- Florida Kidney Physicians - Melbourne — Melbourne, Florida
- Med-Care Research — Miami, Florida
- Professional Research Center — Miami, Florida
- Nephrology Associates of South Miami — Miami, Florida
- On Health Research Center — Miami, Florida
- Combined Research Orlando Phase I-IV — Orlando, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Immunoglobulin A Nephropathy
- Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN) — Birmingham, Alabama
- Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN) — Alabaster, Alabama
- A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy — Birmingham, Alabama
- A Mobile App-Based Study to Evaluate Disease Burden and Treatment Patterns in Immunoglobulin A Nephropathy (IgAN) in the US — Boston, Massachusetts
Explore by condition: All Immunoglobulin A Nephropathy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.