Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML (NCT06578247)
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial Of Quizartinib Administered in Combination With Induction and Consolidation Chemotherapy and Administered as Maintenance Therapy in Adult Patients With Newly Diagnosed FLT3-ITD Negative Acute Myeloid Leukemia
๐ฉบ Plain-English Summary (8th-Grade Level)
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).
Who can join: Review the eligibility criteria below.
Location: City of Hope Phoenix โ Goodyear, Arizona
Age range: 18 Years to 70 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (284 Sites)
Showing the first 25 of 284 sites.
- City of Hope Phoenix โ Goodyear, Arizona
- Mayo Clinic - Phoenix โ Phoenix, Arizona
- University of Arizona Cancer Center โ Tucson, Arizona
- David Geffen School of Medicine โ Los Angeles, California
- University of California Davis Health System โ Sacramento, California
- Ucsf Helen Diller Family Comprehensive Cancer Center โ San Francisco, California
- Stanford University School of Medicine- Parent โ Stanford, California
- Colorado Blood Cancer Institute โ Denver, Colorado
- Yale University โ New Haven, Connecticut
- Sibley Memorial Hospital โ Washington D.C., District of Columbia
- Mayo Clinic Hospital โ Jacksonville, Florida
- Florida Hospital Cancer Institute - Kissimmee โ Kissimmee, Florida
- Tampa General Hospital โ Tampa, Florida
- Moffitt Cancer Center โ Tampa, Florida
- Winship Cancer Institute of Emory University โ Atlanta, Georgia
- Augusta University โ Augusta, Georgia
- Robert H Lurie Comprehensive Cancer Center Northwestern University โ Chicago, Illinois
- University of Illinois Hospital & Health Sciences System โ Chicago, Illinois
- The University of Chicago Medical Center โ Chicago, Illinois
- University of Kentucky โ Lexington, Kentucky
- Ochsner Medical Center - New Orleans โ New Orleans, Louisiana
- Johns Hopkins Hospital โ Baltimore, Maryland
- Massachusetts General Hospital โ Boston, Massachusetts
- University of Michigan Comprehensive Cancer Center Michigan Medicine โ Ann Arbor, Michigan
- University of Minnesota Medical School - Twin Cities Campus โ Minneapolis, Minnesota
๐ Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Leukemia
- Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia โ San Diego, California
- AZD6738 for Patients With Progressive MDS or CMML โ Boston, Massachusetts
- Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies โ Philadelphia, Pennsylvania
- Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 โ New York, New York
- Venetoclax and Chemotherapy as Frontline Therapy in Older Patients and Patients With Relapsed/Refractory ALL โ Chicago, Illinois
- Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors โ Memphis, Tennessee
Explore by condition: All Leukemia clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.