๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-30

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML (NCT06578247)

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial Of Quizartinib Administered in Combination With Induction and Consolidation Chemotherapy and Administered as Maintenance Therapy in Adult Patients With Newly Diagnosed FLT3-ITD Negative Acute Myeloid Leukemia

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Daiichi Sankyo

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).

Who can join: Review the eligibility criteria below.

Location: City of Hope Phoenix โ€” Goodyear, Arizona

Age range: 18 Years to 70 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (284 Sites)

Showing the first 25 of 284 sites.

  • City of Hope Phoenix โ€” Goodyear, Arizona
  • Mayo Clinic - Phoenix โ€” Phoenix, Arizona
  • University of Arizona Cancer Center โ€” Tucson, Arizona
  • David Geffen School of Medicine โ€” Los Angeles, California
  • University of California Davis Health System โ€” Sacramento, California
  • Ucsf Helen Diller Family Comprehensive Cancer Center โ€” San Francisco, California
  • Stanford University School of Medicine- Parent โ€” Stanford, California
  • Colorado Blood Cancer Institute โ€” Denver, Colorado
  • Yale University โ€” New Haven, Connecticut
  • Sibley Memorial Hospital โ€” Washington D.C., District of Columbia
  • Mayo Clinic Hospital โ€” Jacksonville, Florida
  • Florida Hospital Cancer Institute - Kissimmee โ€” Kissimmee, Florida
  • Tampa General Hospital โ€” Tampa, Florida
  • Moffitt Cancer Center โ€” Tampa, Florida
  • Winship Cancer Institute of Emory University โ€” Atlanta, Georgia
  • Augusta University โ€” Augusta, Georgia
  • Robert H Lurie Comprehensive Cancer Center Northwestern University โ€” Chicago, Illinois
  • University of Illinois Hospital & Health Sciences System โ€” Chicago, Illinois
  • The University of Chicago Medical Center โ€” Chicago, Illinois
  • University of Kentucky โ€” Lexington, Kentucky
  • Ochsner Medical Center - New Orleans โ€” New Orleans, Louisiana
  • Johns Hopkins Hospital โ€” Baltimore, Maryland
  • Massachusetts General Hospital โ€” Boston, Massachusetts
  • University of Michigan Comprehensive Cancer Center Michigan Medicine โ€” Ann Arbor, Michigan
  • University of Minnesota Medical School - Twin Cities Campus โ€” Minneapolis, Minnesota

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Leukemia clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—