Leucine in Midlife Depression (NCT06580145)
Leucine as a Probe of Kynurenine-Induced Glutamate and Neural Circuit Dysfunction in Midlife Depression
🩺 Plain-English Summary (8th-Grade Level)
The study aims to investigate the effects of a 6-week leucine challenge on brain chemistry, connectivity, and behavior in people with midlife depression. The researchers will compare the leucine and an active comparator arm (lysine) for 6 weeks.
Who can join: Review the eligibility criteria below.
Location: Emory University Hospital — Atlanta, Georgia
Age range: 35 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Emory University Hospital — Atlanta, Georgia
📞 Contact the Study Coordinator
Phone: (404) 727-8229
Email: eharoon@emory.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Major Depression
- Study of Psilocybin Under Anesthesia Controlled by EEG — Stanford, California
- Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder — Belmont, Massachusetts
- Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 — Belmont, Massachusetts
- Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project — San Francisco, California
- Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression — Belmont, Massachusetts
Explore by condition: All Major Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.