A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease (NCT06587828)
🩺 Plain-English Summary (8th-Grade Level)
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal expansion in the patient's diseased organ. TScan has developed a genome-wide, high-throughput technology to determine the natural, physiological target of any TCR (Kula, 2019). The goal of this study is to isolate T cells from inflamed tissues and matched blood samples and/or matched normal tissues (for patients with inflammatory bowel diseases). T cell clones that are expanded in diseased tissues relative to blood or normal tissues will be selected and the targets of their TCRs will be defined using TScan's genome-wide, high-throughput target ID technology. The goal of this study is to discover a collection of peptide targets, along with their associated TCRs to be developed as new tolerogenic therapies for patients with autoimmune diseases.
Who can join: Review the eligibility criteria below.
Location: Knowledge Research Center — Orange, California
Age range: 18 Years
🧪 Interventions in This Study
- Companion blood samples with procedure (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (12 Sites)
- Knowledge Research Center — Orange, California
- Cura Clinical Research — Sherman Oaks, California
- Arnold Arthritis & Rheumatology — Skokie, Illinois
- University of Kentucky Research Foundation — Lexington, Kentucky
- Massachusetts Eye Research and Surgery Institution (MERSI) — Waltham, Massachusetts
- Susquehanna Research Group — Harrisburg, Pennsylvania
- Nexus Research — Cranston, Rhode Island
- Nexus Research — Cranston, Rhode Island
- RI Rheumatology — Cranston, Rhode Island
- Palmetto Gastroenterology Clinical Research, LLC — Summerville, South Carolina
- Novel Research — Bellaire, Texas
- Medical College of Wisconsin — Milwaukee, Wisconsin
📞 Contact the Study Coordinator
Phone: (857) 399-9930
Email: Lbarefoot@tscan.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Autoimmune Diseases
- A Trial of Academic Detailing to Promote Prescribing of Biosimilars — Louisville, Kentucky
- Maternal Autoimmune Disease Research Alliance (MADRA) Registry — Durham, North Carolina
- Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions — Culver City, California
- Deciphering the Genetic Architecture of Autoimmune Diseases — Bethesda, Maryland
- VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems — Louisville, Kentucky
Explore by condition: All Autoimmune Diseases clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.