Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC). (NCT06600646)
🩺 Plain-English Summary (8th-Grade Level)
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents. Patients with refractory and unexplained chronic cough (RCC/UCC) often exhibit dysregulated vagal pathways, necessitating a neuronal biomarker for targeted treatment. ATP, involved in the ATP/P2X3 pathway, may serve as a potential biomarker due to its role in the cough reflex. The study aims to discover if ATP production by the airway epithelium is greater in RCC/UCC patients compared with healthy controls, if the epithelium is a source of ATP, whether gene and protein expression related to ATP production differs between these groups and whether ATP release is triggered by mechanical and chemical stimulation. Additionally, the study seeks to determine if biomarker gene expression signatures can differentiate RCC/UCC patients from healthy controls.
Who can join: Review the eligibility criteria below.
Location: Imran Satia — Hamilton, Ontario
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
- Bronchoscopy (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Imran Satia — Hamilton, Ontario
📞 Contact the Study Coordinator
Phone: (905) 521-2100
Email: satiai@mcmaster.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Chronic Cough (CC)
- Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough — Aurora, Colorado
- Efficacy of Intramuscular Steroid Injection for Chronic Cough. — Charleston, South Carolina
- The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges — Hamilton, Ontario
Explore by condition: All Chronic Cough (CC) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.