Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial (NCT06601933)
🩺 Plain-English Summary (8th-Grade Level)
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high dose crosswords (4 puzzles per week) to low dose crosswords (1 puzzle per week) and a health education control group on the cognition and function of participants.
Who can join: Review the eligibility criteria below.
Location: University of Miami Miller School of Medicine — Miami, Florida
Age range: 55 Years to 89 Years
🧪 Interventions in This Study
- Cognitive Training (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- University of Miami Miller School of Medicine — Miami, Florida
- Columbia University Irving Medical Center — New York, New York
- Duke University Medical Center — Durham, North Carolina
- University of Washington — Seattle, Washington
📞 Contact the Study Coordinator
Phone: (646) 774-7202
Email: ln2563@cumc.columbia.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Mild Cognitive Impairment (MCI)
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- Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers — La Jolla, California
- AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults — Boston, Massachusetts
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- An Insole and Ankle Device for Monitoring Cognitive Decline in Individuals at Risk for Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD) — Saint Paul, Minnesota
- Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device. — Palisades Park, New Jersey
Explore by condition: All Mild Cognitive Impairment (MCI) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.