๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-18

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors (NCT06625775)

A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-10203 in Subjects With Advanced Solid Tumors (The BREAKER-101 Study)

๐ŸŸข Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kฮฑ:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: City of Hope Comprehensive Cancer Center โ€” Duarte, California

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (40 Sites)

Showing the first 25 of 40 sites.

  • City of Hope Comprehensive Cancer Center โ€” Duarte, California
  • University of California Los Angeles โ€” Los Angeles, California
  • University of California San Diego Moores Cancer Center โ€” San Diego, California
  • UCSF Helen Diller Family Comprehensive Cancer Center โ€” San Francisco, California
  • Moffitt Cancer Center โ€” Tampa, Florida
  • Indiana University Simon Comprehensive Cancer Center โ€” Indianapolis, Indiana
  • Massachusetts General Hospital โ€” Boston, Massachusetts
  • Dana-Farber Cancer Insitute โ€” Boston, Massachusetts
  • St. Lukes Hospital of Kansas City โ€” Kansas City, Missouri
  • Washington University School of Medicine โ€” St Louis, Missouri
  • Columbia University Irving Medical Center โ€” New York, New York
  • Memorial Sloan Kettering Cancer Center โ€” New York, New York
  • SCRI Oncology Partners โ€” Nashville, Tennessee
  • SCRI at Mary Crowley โ€” Dallas, Texas
  • University of Texas Southwestern Medical Center โ€” Dallas, Texas
  • The University of Texas MD Anderson Cancer Center โ€” Houston, Texas
  • University of Texas San Antonio (UTSA) โ€” San Antonio, Texas
  • Fred Hutchinson Cancer Center โ€” Seattle, Washington
  • Wisconsin Institute for Medical Research โ€” Madison, Wisconsin
  • Scientia Clinical Research โ€” Randwick, New South Wales
  • Peter MacCallum Cancer Centre โ€” Melbourne, Victoria
  • FUTTURA Oncologia โ€” Porto Alegre, Rio Grande do Sul
  • Hospital Sรฃo Lucas da PUCRS โ€” Porto Alegre, Rio Grande do Sul
  • Clinica de Pesquisas e Centro de Estudos Em Oncologia Ginecologica e Mamaria Ltda โ€” Sรฃo Paulo, Sรฃo Paulo
  • IEPE - Unimed Sorocaba โ€” Sorocaba, Sรฃo Paulo

๐Ÿ“ž Contact the Study Coordinator

Phone: (650) 405-8440

Email: Breaker-101ct.gov@bridgebiooncology.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—