Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors (NCT06625775)
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-10203 in Subjects With Advanced Solid Tumors (The BREAKER-101 Study)
๐ฉบ Plain-English Summary (8th-Grade Level)
First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kฮฑ:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.
Who can join: Review the eligibility criteria below.
Location: City of Hope Comprehensive Cancer Center โ Duarte, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (40 Sites)
Showing the first 25 of 40 sites.
- City of Hope Comprehensive Cancer Center โ Duarte, California
- University of California Los Angeles โ Los Angeles, California
- University of California San Diego Moores Cancer Center โ San Diego, California
- UCSF Helen Diller Family Comprehensive Cancer Center โ San Francisco, California
- Moffitt Cancer Center โ Tampa, Florida
- Indiana University Simon Comprehensive Cancer Center โ Indianapolis, Indiana
- Massachusetts General Hospital โ Boston, Massachusetts
- Dana-Farber Cancer Insitute โ Boston, Massachusetts
- St. Lukes Hospital of Kansas City โ Kansas City, Missouri
- Washington University School of Medicine โ St Louis, Missouri
- Columbia University Irving Medical Center โ New York, New York
- Memorial Sloan Kettering Cancer Center โ New York, New York
- SCRI Oncology Partners โ Nashville, Tennessee
- SCRI at Mary Crowley โ Dallas, Texas
- University of Texas Southwestern Medical Center โ Dallas, Texas
- The University of Texas MD Anderson Cancer Center โ Houston, Texas
- University of Texas San Antonio (UTSA) โ San Antonio, Texas
- Fred Hutchinson Cancer Center โ Seattle, Washington
- Wisconsin Institute for Medical Research โ Madison, Wisconsin
- Scientia Clinical Research โ Randwick, New South Wales
- Peter MacCallum Cancer Centre โ Melbourne, Victoria
- FUTTURA Oncologia โ Porto Alegre, Rio Grande do Sul
- Hospital Sรฃo Lucas da PUCRS โ Porto Alegre, Rio Grande do Sul
- Clinica de Pesquisas e Centro de Estudos Em Oncologia Ginecologica e Mamaria Ltda โ Sรฃo Paulo, Sรฃo Paulo
- IEPE - Unimed Sorocaba โ Sorocaba, Sรฃo Paulo
๐ Contact the Study Coordinator
Phone: (650) 405-8440
Email: Breaker-101ct.gov@bridgebiooncology.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Solid Tumor, Adult
- A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody โ Sarasota, Florida
- First-in-Human Study of ICT01 in Patients With Advanced Cancer โ Gilbert, Arizona
- A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors โ Los Angeles, California
- Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab โ Los Angeles, California
- A Rollover Study for Subjects Who Completed Participation in IMSA101-101 Trial โ Scottsdale, Arizona
- A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression โ Gilbert, Arizona
Explore by condition: All Solid Tumor, Adult clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.