🏛️ Verified NIH Record • Updated 2026-08-03

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01) (NCT06644781)

A Phase 3, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Daiichi Sankyo

🩺 Plain-English Summary (8th-Grade Level)

This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC) who have experienced disease progression following treatment with a platinum-based systemic therapy and an immune checkpoint inhibitor (ICI) compared with investigator's choice of chemotherapy (ICC).

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic Hospital — Phoenix, Arizona

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (132 Sites)

Showing the first 25 of 132 sites.

  • Mayo Clinic Hospital — Phoenix, Arizona
  • Providence Medical Foundation — Fullerton, California
  • Univ of California Irvine College of Medicine — Orange, California
  • Henry Ford Health System — Detroit, Michigan
  • Mayo Clinic Rochester — Rochester, Minnesota
  • MidAmerica Cancer Care - American Oncology Partners — Kansas City, Missouri
  • Morristown Medical Center — Morristown, New Jersey
  • Maimonides Cancer Center — Brooklyn, New York
  • Penn State University Milton S. Hershey Medical Center — Hershey, Pennsylvania
  • Baptist Cancer Center — Memphis, Tennessee
  • SCRI Oncology Partners — Nashville, Tennessee
  • John Peter Smith Hospital — Fort Worth, Texas
  • Virginia Cancer Specialists — Fairfax, Virginia
  • Institut Jules Bordet — Brussels,
  • Cliniques Universitaires Saint-Luc — Brussels,
  • Antwerp University Hospital — Edegem,
  • UZ Leuven — Leuven,
  • Chu de Liege — Liège,
  • Anyang Cancer Hospital — Anyang,
  • Beijing Cancer Hospital — Beijing,
  • Jilin Cancer Hospital — Changchun,
  • Changzhou Cancer Hospital — Changzhou,
  • Sichuan cancer hospital — Chengdu,
  • West China Hospital Sichuan University — Chengdu,
  • Fujian Cancer Hospital — Fuzhou,

📞 Contact the Study Coordinator

Phone: (908) 992-6400

Email: CTRinfo_us@daiichisankyo.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗