A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01) (NCT06644781)
A Phase 3, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
🩺 Plain-English Summary (8th-Grade Level)
This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC) who have experienced disease progression following treatment with a platinum-based systemic therapy and an immune checkpoint inhibitor (ICI) compared with investigator's choice of chemotherapy (ICC).
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic Hospital — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (132 Sites)
Showing the first 25 of 132 sites.
- Mayo Clinic Hospital — Phoenix, Arizona
- Providence Medical Foundation — Fullerton, California
- Univ of California Irvine College of Medicine — Orange, California
- Henry Ford Health System — Detroit, Michigan
- Mayo Clinic Rochester — Rochester, Minnesota
- MidAmerica Cancer Care - American Oncology Partners — Kansas City, Missouri
- Morristown Medical Center — Morristown, New Jersey
- Maimonides Cancer Center — Brooklyn, New York
- Penn State University Milton S. Hershey Medical Center — Hershey, Pennsylvania
- Baptist Cancer Center — Memphis, Tennessee
- SCRI Oncology Partners — Nashville, Tennessee
- John Peter Smith Hospital — Fort Worth, Texas
- Virginia Cancer Specialists — Fairfax, Virginia
- Institut Jules Bordet — Brussels,
- Cliniques Universitaires Saint-Luc — Brussels,
- Antwerp University Hospital — Edegem,
- UZ Leuven — Leuven,
- Chu de Liege — Liège,
- Anyang Cancer Hospital — Anyang,
- Beijing Cancer Hospital — Beijing,
- Jilin Cancer Hospital — Changchun,
- Changzhou Cancer Hospital — Changzhou,
- Sichuan cancer hospital — Chengdu,
- West China Hospital Sichuan University — Chengdu,
- Fujian Cancer Hospital — Fuzhou,
📞 Contact the Study Coordinator
Phone: (908) 992-6400
Email: CTRinfo_us@daiichisankyo.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Esophageal Squamous Cell Carcinoma
- A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy — Fort Myers, Florida
- Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC — Atlanta, Georgia
- Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) — Pittsburgh, Pennsylvania
- A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B) — Tucson, Arizona
- Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer — Montreal, Quebec
- A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types — Denver, Colorado
Explore by condition: All Esophageal Squamous Cell Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.