Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest (NCT06654557)
🩺 Plain-English Summary (8th-Grade Level)
The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention. In addition, inclusion of glycerol resulted in an upward shift in the relationship between sodium concentration and fluid balance. The practical interpretation is that addition of glycerol enables a reduction in sodium concentration compared with a 0% glycerol drink. In this follow-up study, the investigators hypothesize that 1) fluid balance will be sustained (greater than or not different from baseline) and significantly greater than placebo for 120 min after drinking the test no/low/moderate carbohydrate beverages and 2) fluid balance will not differ between the carbohydrate-electrolyte beverages, but both will be greater than placebo.
Who can join: Review the eligibility criteria below.
Location: PepsiCo R&D, Gatorade Sports Science Institute — Valhalla, New York
Age range: 18 Years to 50 Years
🧪 Interventions in This Study
- Placebo beverage, kiwi-strawberry flavor (Part 1 and Part 2) (OTHER)
- 0% carbohydrate electrolyte solution with glycerol beverage (Part 1 only) (OTHER)
- 0% carbohydrate electrolyte solution without glycerol beverage (Part 1 only) (OTHER)
- 1% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2) (OTHER)
- 6% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2) (OTHER)
- 6% carbohydrate electrolyte solution without glycerol beverage (Part 2 only) (OTHER)
- 2% carbohydrate electrolyte solution without glycerol beverage (Part 2 only) (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- PepsiCo R&D, Gatorade Sports Science Institute — Valhalla, New York
📞 Contact the Study Coordinator
Phone: (814) 883-9454
Email: Lindsay.Baker@pepsico.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Fluid Balance
Explore by condition: All Fluid Balance clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.