A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA) (NCT06706622)
Interventional, Randomized, Double-blind, Placebo-controlled, Optional Open-label Extension Trial of Lu AF82422 in Participants With Multiple System Atrophy
๐ฉบ Plain-English Summary (8th-Grade Level)
The main goal of this trial is to evaluate the efficacy and safety of amlenetug for the treatment of participants with Multiple System Atrophy (MSA).
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic โ Scottsdale, Arizona
Age range: 40 Years to 75 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (74 Sites)
Showing the first 25 of 74 sites.
- Mayo Clinic โ Scottsdale, Arizona
- University of Arkansas for Medical Sciences โ Little Rock, Arkansas
- University of California, San Francisco Neurosciences Clinical Research Unit โ San Francisco, California
- CenExel Rocky Mountain Clinical Research, LLC โ Englewood, Colorado
- Yale New Haven Health โ North Haven, Connecticut
- Parkinson's Disease And Movement Disorder Center Of Boca Raton โ Boca Raton, Florida
- University of Florida Norman Fixel Institute for Neurological Diseases โ Gainesville, Florida
- Indiana Health University โ Indianapolis, Indiana
- Johns Hopkins University School of Medicine โ Baltimore, Maryland
- Brigham and Women's Hospital โ Boston, Massachusetts
- Beth Israel Deaconess Medical Center โ Boston, Massachusetts
- QUEST Research Institute โ Farmington Hills, Michigan
- Mayo Clinic โ Rochester, Minnesota
- University Nebraska Medical Center โ Omaha, Nebraska
- NYU Medical Center - Dysautonomia center โ New York, New York
- Columbia University Medical Center - The Neurological Institute of New York โ New York, New York
- Cleveland Clinic - Neurological Institute โ Cleveland, Ohio
- University of Pennsylvania โ Philadelphia, Pennsylvania
- University Of Pittsburgh โ Pittsburgh, Pennsylvania
- Vanderbilt University Medical Center-Cognitive and Movement Disorders Group โ Nashville, Tennessee
- University of Texas Southwestern Medical Center ยฟ Multiple System Atrophy Clinic โ Dallas, Texas
- Baylor College Of Medicine โ Houston, Texas
- Inland Northwest Research โ Spokane, Washington
- Liverpool Hospital - South Western Sydney Local Health District โ Liverpool, New South Wales
- Westmead Hospital โ Westmead, New South Wales
๐ Contact the Study Coordinator
Phone: (800) 664-4580
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Multiple System Atrophy
- Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy โ Rochester, Minnesota
- A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy โ Los Angeles, California
- A Study of Lu AF82422 in Participants With Multiple System Atrophy โ Fountain Valley, California
- GDNF Gene Therapy for Multiple System Atrophy โ Irvine, California
- Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic โ Nashville, Tennessee
Explore by condition: All Multiple System Atrophy clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.