๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-13

A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA) (NCT06706622)

Interventional, Randomized, Double-blind, Placebo-controlled, Optional Open-label Extension Trial of Lu AF82422 in Participants With Multiple System Atrophy

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: H. Lundbeck A/S

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The main goal of this trial is to evaluate the efficacy and safety of amlenetug for the treatment of participants with Multiple System Atrophy (MSA).

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic โ€” Scottsdale, Arizona

Age range: 40 Years to 75 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (74 Sites)

Showing the first 25 of 74 sites.

  • Mayo Clinic โ€” Scottsdale, Arizona
  • University of Arkansas for Medical Sciences โ€” Little Rock, Arkansas
  • University of California, San Francisco Neurosciences Clinical Research Unit โ€” San Francisco, California
  • CenExel Rocky Mountain Clinical Research, LLC โ€” Englewood, Colorado
  • Yale New Haven Health โ€” North Haven, Connecticut
  • Parkinson's Disease And Movement Disorder Center Of Boca Raton โ€” Boca Raton, Florida
  • University of Florida Norman Fixel Institute for Neurological Diseases โ€” Gainesville, Florida
  • Indiana Health University โ€” Indianapolis, Indiana
  • Johns Hopkins University School of Medicine โ€” Baltimore, Maryland
  • Brigham and Women's Hospital โ€” Boston, Massachusetts
  • Beth Israel Deaconess Medical Center โ€” Boston, Massachusetts
  • QUEST Research Institute โ€” Farmington Hills, Michigan
  • Mayo Clinic โ€” Rochester, Minnesota
  • University Nebraska Medical Center โ€” Omaha, Nebraska
  • NYU Medical Center - Dysautonomia center โ€” New York, New York
  • Columbia University Medical Center - The Neurological Institute of New York โ€” New York, New York
  • Cleveland Clinic - Neurological Institute โ€” Cleveland, Ohio
  • University of Pennsylvania โ€” Philadelphia, Pennsylvania
  • University Of Pittsburgh โ€” Pittsburgh, Pennsylvania
  • Vanderbilt University Medical Center-Cognitive and Movement Disorders Group โ€” Nashville, Tennessee
  • University of Texas Southwestern Medical Center ยฟ Multiple System Atrophy Clinic โ€” Dallas, Texas
  • Baylor College Of Medicine โ€” Houston, Texas
  • Inland Northwest Research โ€” Spokane, Washington
  • Liverpool Hospital - South Western Sydney Local Health District โ€” Liverpool, New South Wales
  • Westmead Hospital โ€” Westmead, New South Wales

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 664-4580

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—