🏛️ Verified NIH Record • Updated 2026-07-29

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) (NCT06710132)

PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants With Advanced Solid Tumors (Master Protocol)

🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: EMD Serono Research & Development Institute, Inc.

🩺 Plain-English Summary (8th-Grade Level)

The PROCEADE PanTumor study aims to investigate M9140 in multiple tumor types which express carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and it is therefore designed as a matrix study. This study aims to assess the antitumor activity, tolerability, safety, and pharmacokinetics (PK) of M9140 as monotherapy or in combination treatments in adult participants with locally advanced/metastatic CEACAM5 expressing tumors. There will be 3 substudies under this Master Protocol that may be conducted in parallel. * PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants with Advanced Gastric Cancer (Substudy GC); * PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants with Advanced Non-Small Cell Lung Cancer (Substudy NSCLC); * PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants With Advanced Pancreatic Cancer (Substudy PDAC).

Who can join: Review the eligibility criteria below.

Location: University of California - Los Angeles - 300208353 — Santa Monica, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

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Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (81 Sites)

Showing the first 25 of 81 sites.

  • University of California - Los Angeles - 300208353 — Santa Monica, California
  • Providence Medical Foundation — Santa Rosa, California
  • Georgetown University - Lombardi Comprehensive Cancer Center - 1134847 — Washington D.C., District of Columbia
  • D&H Cancer Research Center — Margate, Florida
  • Prisma Health Cancer Institute, ITOR, CRU — Greenville, South Carolina
  • Baptist Cancer Center — Memphis, Tennessee
  • The University of Texas MD Anderson Cancer Center — Houston, Texas
  • NEXT Virginia — Fairfax, Virginia
  • Flinders Medical Centre — Bedford Park,
  • Nepean Cancer Care Centre — Kingswood,
  • Mater Misericordiae Ltd - PARENT — South Brisbane,
  • Macquarie University Hospital - PARENT — Sydney,
  • Ordensklinikum Linz Krankenhaus der Elisabethinen Linz - Pneumology — Linz,
  • LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie — Salzburg,
  • Medical University of Vienna - Department of Internal Medicine — Vienna,
  • Anhui Provincial Cancer Hospital — Hefei, Anhui
  • Beijing Cancer Hospital — Beijing, Beijing Municipality
  • Sun Yat-sen University Cancer Center — Guangzhou, Guangzhou
  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hebei
  • Harbin Medical University Cancer Hospital — Harbin, Heilongjiang
  • Xiangya Hospital, Central South University — Changsha, Hu'nan
  • Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology — Wuhan, Hubei
  • Sichuan Cancer Hospital — Chengdu, Sichuan
  • West China Hospital, Sichuan University — Chengdu, Sichuan
  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - Department of Oncology Surgery — Hangzhou, Zhejiang

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Solid Tumors clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗