Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) (NCT06710132)
PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants With Advanced Solid Tumors (Master Protocol)
🩺 Plain-English Summary (8th-Grade Level)
The PROCEADE PanTumor study aims to investigate M9140 in multiple tumor types which express carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and it is therefore designed as a matrix study. This study aims to assess the antitumor activity, tolerability, safety, and pharmacokinetics (PK) of M9140 as monotherapy or in combination treatments in adult participants with locally advanced/metastatic CEACAM5 expressing tumors. There will be 3 substudies under this Master Protocol that may be conducted in parallel. * PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants with Advanced Gastric Cancer (Substudy GC); * PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants with Advanced Non-Small Cell Lung Cancer (Substudy NSCLC); * PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants With Advanced Pancreatic Cancer (Substudy PDAC).
Who can join: Review the eligibility criteria below.
Location: University of California - Los Angeles - 300208353 — Santa Monica, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (81 Sites)
Showing the first 25 of 81 sites.
- University of California - Los Angeles - 300208353 — Santa Monica, California
- Providence Medical Foundation — Santa Rosa, California
- Georgetown University - Lombardi Comprehensive Cancer Center - 1134847 — Washington D.C., District of Columbia
- D&H Cancer Research Center — Margate, Florida
- Prisma Health Cancer Institute, ITOR, CRU — Greenville, South Carolina
- Baptist Cancer Center — Memphis, Tennessee
- The University of Texas MD Anderson Cancer Center — Houston, Texas
- NEXT Virginia — Fairfax, Virginia
- Flinders Medical Centre — Bedford Park,
- Nepean Cancer Care Centre — Kingswood,
- Mater Misericordiae Ltd - PARENT — South Brisbane,
- Macquarie University Hospital - PARENT — Sydney,
- Ordensklinikum Linz Krankenhaus der Elisabethinen Linz - Pneumology — Linz,
- LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie — Salzburg,
- Medical University of Vienna - Department of Internal Medicine — Vienna,
- Anhui Provincial Cancer Hospital — Hefei, Anhui
- Beijing Cancer Hospital — Beijing, Beijing Municipality
- Sun Yat-sen University Cancer Center — Guangzhou, Guangzhou
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hebei
- Harbin Medical University Cancer Hospital — Harbin, Heilongjiang
- Xiangya Hospital, Central South University — Changsha, Hu'nan
- Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology — Wuhan, Hubei
- Sichuan Cancer Hospital — Chengdu, Sichuan
- West China Hospital, Sichuan University — Chengdu, Sichuan
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - Department of Oncology Surgery — Hangzhou, Zhejiang
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial — Porto Alegre, Rio Grande do Sul
- Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors — Los Angeles, California
- Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors — Phoenix, Arizona
Explore by condition: All Solid Tumors clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.