A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors (NCT06710847)
A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Expansion Study of the Oral DNA Helicase Werner Inhibitor (WRNi) GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Adult Participants With Mismatch Repair-deficient (dMMR) or Microsatellite Instability-High (MSI-H) Solid Tumors (SYLVER)
🩺 Plain-English Summary (8th-Grade Level)
Solid tumours are abnormal lumps of tissue that can occur in different parts of the body. The tumours involved in this study have specific genetic characteristics that can make them more aggressive and challenging to treat. The study will test whether GSK4418959 alone or in combination with a PD-1 inhibitor agent can decrease tumor size, is safe, well-tolerated, and how amounts of the study drug decrease in the body over time.
Who can join: Review the eligibility criteria below.
Location: GSK Investigational Site — Los Angeles, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (22 Sites)
- GSK Investigational Site — Los Angeles, California
- GSK Investigational Site — Denver, Colorado
- GSK Investigational Site — Detroit, Michigan
- GSK Investigational Site — New York, New York
- GSK Investigational Site — Philadelphia, Pennsylvania
- GSK Investigational Site — Philadelphia, Pennsylvania
- GSK Investigational Site — Melbourne, Victoria
- GSK Investigational Site — Brussels,
- GSK Investigational Site — Ghent,
- GSK Investigational Site — Leuven,
- GSK Investigational Site — Chiba,
- GSK Investigational Site — Shizuoka,
- GSK Investigational Site — Tokyo,
- GSK Investigational Site — Tokyo,
- GSK Investigational Site — Amsterdam,
- GSK Investigational Site — Daegu,
- GSK Investigational Site — Gyeonggi-do,
- GSK Investigational Site — Seoul,
- GSK Investigational Site — Barcelona,
- GSK Investigational Site — Barcelona,
- GSK Investigational Site — Madrid,
- GSK Investigational Site — Málaga,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.