🏛️ Verified NIH Record • Updated 2026-01-15

Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma (NCT06712459)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: International Extranodal Lymphoma Study Group (IELSG)

🩺 Plain-English Summary (8th-Grade Level)

Histological transformation in Splenic Marginal Zone Lymphoma (t-SMZL) represents an unmet clinical and biological need, invariably associated with poor prognosis and reduced overall survival. At the present time, there are no recommended treatments intended specifically to t-SMZL and little is known about t-SMZL genetic complexity. The aim of this study is to provide information that will help clinicians to better understand the complexity of the disease. The information gained from this study will also lead to more specific and effective treatment for patients with t-SMZL.

Who can join: Review the eligibility criteria below.

Location: Columbia University — New York, New York

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (7 Sites)

  • Columbia University — New York, New York
  • Universitz Hospitals Leuven — Leuven,
  • Hôpital Saint Louis — Paris,
  • Fondazione IRCCS Policlinico San Matteo — Pavia,
  • Hospital Clínic de Barcelona — Barcelona,
  • Oncology Institute of Southern Switzerland — Bellinzona,
  • University Hospitals Dorset — Bournemouth,

📞 Contact the Study Coordinator

Phone: +41 58 666 7321

Email: ielsg@ior.usi.ch

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗