Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy (NCT06780670)
PSMAcTION: A Phase II/III, Open-label, International, Multicenter, Randomized Study of AAA817 Versus Standard of Care in the Treatment of Adult Participants With PSMA Positive Metastatic Castration-resistant Prostate Cancer Who Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and progressed on or after \[177Lu\]Lu-PSMA targeted therapy. Treatment of interest: the investigational treatment is AAA817 regardless of subsequent anti-neoplastic treatment. The control treatment is investigator's choice of Standard of Care, regardless of subsequent anti-neoplastic treatment
Who can join: Review the eligibility criteria below.
Location: VA Greater LA Healthcare System — Los Angeles, California
Age range: 18 Years to 100 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (81 Sites)
Showing the first 25 of 81 sites.
- VA Greater LA Healthcare System — Los Angeles, California
- VA Palo Alto Health Care System — Palo Alto, California
- Stanford University Medical Center — Palo Alto, California
- Sansum Clinic — Santa Barbara, California
- Saint Johns Cancer Institute — Santa Monica, California
- Hartford Hospital — Hartford, Connecticut
- AdventHealth — Orlando, Florida
- University Cancer and Blood Center LLC — Athens, Georgia
- Emory University — Atlanta, Georgia
- Indiana University — Indianapolis, Indiana
- University of Kansas Hospital — Kansas City, Kansas
- East Jefferson Hospital — Metairie, Louisiana
- Dana Farber Cancer Institute — Boston, Massachusetts
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- WA Uni School Of Med — St Louis, Missouri
- Nebraska Cancer Specialists — Omaha, Nebraska
- New Jersey Urology LLC — Voorhees Township, New Jersey
- Associated Med Professionals of NY — Syracuse, New York
- Montefiore Medical Center — The Bronx, New York
- Central Ohio Urology Group — Gahanna, Ohio
- Fox Chase Cancer Center — Philadelphia, Pennsylvania
- Carolina Urologic Research Center — Myrtle Beach, South Carolina
- Texas Oncology — Dallas, Texas
- Urology San Antonio — San Antonio, Texas
- Utah Intermountain Medical Center — Murray, Utah
📞 Contact the Study Coordinator
Phone: (888) 669-6682
Email: novartis.email@novartis.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.