First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma (NCT06797999)
A First-in-human, Phase 1/2, Multicenter, Open-label, Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of ADCE-D01, a Humanized Anti-human uPARAP Antibody Linked to a Topoisomerase I Inhibitor, in Patients With Metastatic and/or Unresectable Soft Tissue Sarcoma
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to learn about the safety, tolerability and efficacy of ADCE-D01.
Who can join: Review the eligibility criteria below.
Location: University of Colorado Denver — Aurora, Colorado
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (8 Sites)
- University of Colorado Denver — Aurora, Colorado
- University of Miami - Sylvester Comprehensive Cancer Center — Miami, Florida
- Memorial Sloan Kettering Cancer Center — New York, New York
- University Of Texas MD Anderson Cancer Center — Houston, Texas
- Universitair Ziekenhuis Leuven (UZ Leuven) - Campus Gasthuisberg — Leuven,
- Centre Léon Bérard — Lyon,
- Universitätsklinikum Essen West German Tumor Center — Essen,
- Royal Marsden — London,
📞 Contact the Study Coordinator
Phone: (453) 144-0653
Email: rene.smrcka@adcendo.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Metastatic Soft Tissue Sarcoma
- Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas — Aurora, Colorado
Explore by condition: All Metastatic Soft Tissue Sarcoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.