Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults (NCT06811324)
The Effects of Tirzepatide Use on Muscle and Vascular Function Among Obese Older Adults
🩺 Plain-English Summary (8th-Grade Level)
Obesity and type 2 diabetes mellitus (T2DM) represent major public health concerns in the aging community. Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist recently approved for the treatment of T2DM and obesity has been shown to be effective at reducing weight, improving markers of T2DM control, and improving cardiovascular health. Utilization of tirzepatide among older adults has been on the rise since FDA approval was issued, however the effects of tirzepatide use on functional outcomes in older adults with obesity are not well established. Recent studies show that weight loss caused by tirzepatide may be driven by substantial loss of lean muscle mass, which may contribute to weakness and frailty, particularly among older adults. The proposed pilot study aims to evaluate how treatment with tirzepatide for 6 months affects muscle mass and function among older adults, and if changes in muscle mass are linked to changes in functional status over the same time period.
Who can join: Review the eligibility criteria below.
Location: University of Texas Health Science Center at San Antonio — San Antonio, Texas
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Texas Health Science Center at San Antonio — San Antonio, Texas
📞 Contact the Study Coordinator
Phone: (210) 450-3333
Email: BCRU@uthscsa.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Obesity Prevention
- Childhood Obesity Management Using Innovative Digital Technology — Victoria, British Columbia
- Primary Prevention of Obesity in American Indian Youth in Rural Tribal Schools — Flagstaff, Arizona
- Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance — Birmingham, Alabama
- Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions — San Diego, California
- Pennington Generation Cohort — Baton Rouge, Louisiana
Explore by condition: All Obesity Prevention clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.