Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab (NCT06816927)
A Multi-Center, Randomized, Phase 2 Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab (GIANT)
🩺 Plain-English Summary (8th-Grade Level)
GIANT is an open-label, multi-center, randomized, perioperative (neoadjuvant followed by adjuvant), phase 2 trial with a safety lead-in phase to investigate the feasibility, safety and tolerability, and establish the biological activity of nivolumab with or without relatlimab in patients with isocitrate dehydrogenase (IDH) wildtype newly diagnosed glioblastoma (ndGBM).
Who can join: Review the eligibility criteria below.
Location: Memorial Sloan Kettering Cancer Center — New York, New York
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Memorial Sloan Kettering Cancer Center — New York, New York
- Duke University — Durham, North Carolina
- Peter MacCallum Cancer Centre — Parkville, Victoria
📞 Contact the Study Coordinator
Phone: (919) 684-5301
Email: mustafa.khasraw@duke.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Newly Diagnosed Glioblastoma
- BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma — Durham, North Carolina
- Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma — Chicago, Illinois
- Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma — Seattle, Washington
Explore by condition: All Newly Diagnosed Glioblastoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.