🏛️ Verified NIH Record • Updated 2026-05-04

The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study (NCT06839300)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: AO Foundation, AO Spine

🩺 Plain-English Summary (8th-Grade Level)

To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.

Who can join: Review the eligibility criteria below.

Location: Medical College of Wisconsin — Milwaukee, Wisconsin

Age range: 19 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (8 Sites)

  • Medical College of Wisconsin — Milwaukee, Wisconsin
  • Prince of Wales Hospital — Sydney, Randwick NSW
  • Cajuru University Hospital — Curitiba, Paraná
  • Clinica Alemana de Santiago — Santiago, Vitacura
  • Charité Berlin — Berlin,
  • Sri Balaji Action Medical Institute — New Delhi,
  • MIddlemore Hospital — Auckland, Otahuhu
  • King's College Hospital — London,

📞 Contact the Study Coordinator

Phone: +41 79 606 41 48

Email: alix.frischknecht@aofoundation.org

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗