A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM (NCT06845202)
A Phase 1/2, Randomized, Double-blind, Placebo-controlled 2-part Study of the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Single Dose ALN-4324 in Overweight to Obese Adult Healthy Volunteers and Multiple Dose ALN-4324 in Overweight to Obese Patients With Type 2 Diabetes Mellitus (T2DM)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to: * evaluate the safety and tolerability of single ascending doses of ALN-4324 in healthy volunteers and to characterize the single-dose PK of ALN-4324 * evaluate the efficacy, safety, tolerability, PK, and pharmacodynamics (PD) of multiple doses of ALN-4324 in adult overweight to obese patients with T2DM
Who can join: Review the eligibility criteria below.
Location: Clinical Trial Site — Montclair, California
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (22 Sites)
- Clinical Trial Site — Montclair, California
- Clinical Trial Site — Washington D.C., District of Columbia
- Clinical Trial Site — Miami, Florida
- Clinical Trial Site — Marlton, New Jersey
- Clinical Trial Site — Monroe, North Carolina
- Clinical Trial Site — Dallas, Texas
- Clinical Trial Site — Dallas, Texas
- Clinical Trial Site — Buenos Aires,
- Clinical Trial Site — Buenos Aires,
- Clinical Trial Site — Buenos Aires,
- Clinical Trial Site — San Miguel de Tucumán,
- Clinical Trial Site — Concord,
- Clinical Trial Site — Mount Royal,
- Clinical Trial Site — Vancouver,
- Clinical Trial Site — Santiago,
- Clinical Trial Site — Santiago,
- Clinical Trial Site — Santiago,
- Clinical Trial Site — Essen,
- Clinical Trial Site — Gdansk,
- Clinical Trial Site — Tarnów,
- Clinical Trial Site — Warsaw,
- Clinical Trial Site — Wroclaw,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Obese or Overweight Healthy Volunteers clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.