A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks (NCT06851559)
A Phase 2, Randomized, Double-Blind, Multi-Center Study in Adult Subjects With Eosinophilic Esophagitis (EoE) to Evaluate the Safety and Efficacy of Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate the Safety and Efficacy of Vonoprazan 20 mg Up to 24 Weeks
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to assess the efficacy of vonoprazan 20 mg once daily (QD) compared to placebo QD in the number of participants with a peak eosinophilic histologic response \<15 eosinophils per high-power field (eos/hpf) after 12 weeks of therapy.
Who can join: Review the eligibility criteria below.
Location: Preferred Research Partners, Inc — Little Rock, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (41 Sites)
Showing the first 25 of 41 sites.
- Preferred Research Partners, Inc — Little Rock, Arkansas
- GW Research, Inc — Chula Vista, California
- Southern California Research Institute Medical Group — Los Angeles, California
- Rocky Mountain Gastroenterology — Lakewood, Colorado
- Western States Clinical Research, Inc. — Wheat Ridge, Colorado
- Connecticut Clinical Research Institute — Bristol, Connecticut
- Nature Coast Clinical Research — Inverness, Florida
- Encore Borland-Groover Clinical Research — Jacksonville, Florida
- International Center for Research — Tampa, Florida
- Gastroenterology Associates of Central Georgia, LLC — Macon, Georgia
- Treasure Valley Medical Research — Boise, Idaho
- Grand Teton Research Group — Idaho Falls, Idaho
- Northwestern Medicine Digestive Health Center — Chicago, Illinois
- GI Alliance - Gurnee — Gurnee, Illinois
- Combined Gastro, LLC — Lafayette, Louisiana
- Tandem Clinical Research GI, LLC — Marrero, Louisiana
- Woodholme Gastroenterology Associates — Glen Burnie, Maryland
- Boston Specialists — Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts
- Huron Gastroenterology Associates — Ypsilanti, Michigan
- Advanced Research Institute — Reno, Nevada
- Weill Cornell Medicine, New York Presbyterian Hospital — New York, New York
- UNC Clinical & Translational Research Center — Chapel Hill, North Carolina
- GCGA Physicians, LLC dba/Gastro Health Research — Cincinnati, Ohio
- Great Lakes Gastroenterology Research LLC — Mentor, Ohio
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Eosinophilic Esophagitis
- Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis — Phoenix, Arizona
- Efficacy of Low-Dose Topical Steroids in Maintaining Remission of Eosinophilic Esophagitis in Children — Chicago, Illinois
- A Prospective Study of the Four Food Elimination Diet for Treatment of Eosinophilic Esophagitis — Chicago, Illinois
- Dupilumab for Eosinophilic Esophagitis With Severe Strictures — Chapel Hill, North Carolina
- Cow's Milk Elimination for Treatment of Eosinophilic Esophagitis — Chicago, Illinois
Explore by condition: All Eosinophilic Esophagitis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.