A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity (NCT06859268)
A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Retatrutide Treatment in the Maintenance of Weight Reduction in Individuals With Obesity
🩺 Plain-English Summary (8th-Grade Level)
This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks.
Who can join: Review the eligibility criteria below.
Location: Southern California Clinical Research — Santa Ana, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (53 Sites)
Showing the first 25 of 53 sites.
- Southern California Clinical Research — Santa Ana, California
- University of Colorado Anschutz Medical Campus — Aurora, Colorado
- CMR of Greater New Haven, LLC — Hamden, Connecticut
- ALL Medical Research, LLC — Cooper City, Florida
- Florida International Medical Research — Coral Gables, Florida
- Renstar Medical Research — Ocala, Florida
- Charter Research - Winter Park — Orlando, Florida
- Metabolic Research Institute, Inc. — West Palm Beach, Florida
- Kubost Clinical Research - Marietta — Marietta, Georgia
- North Georgia Clinical Research — Woodstock, Georgia
- Pacific Diabetes & Endocrine Center — Honolulu, Hawaii
- Alliance for Multispecialty Research, LLC — Oak Brook, Illinois
- Springfield Clinic Main Campus — Springfield, Illinois
- Alliance for Multispecialty Research, LLC — Lexington, Kentucky
- L-MARC Research Center — Louisville, Kentucky
- Pennington Biomedical Research Center — Baton Rouge, Louisiana
- Care Access - Lake Charles (Bayou Pines) — Lake Charles, Louisiana
- Massachusetts General Hospital — Boston, Massachusetts
- Alliance for Multispecialty Research, LLC — Kansas City, Missouri
- Vector Clinical Trials — Las Vegas, Nevada
- Dent Neurosciences Research Center, Inc — Amherst, New York
- Carteret Medical Group — Morehead City, North Carolina
- Care Access - Raleigh — Raleigh, North Carolina
- Tekton Research, LLC. — Moore, Oklahoma
- Altoona Center For Clinical Research — Duncansville, Pennsylvania
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Obesity
- Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools — Tampa, Florida
- SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity — Tucson, Arizona
- Piloting a Patient Navigator Program for Weight Loss — Philadelphia, Pennsylvania
- Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) — Mesa, Arizona
- Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects — Orlando, Florida
- Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans — Pittsburgh, Pennsylvania
Explore by condition: All Obesity clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.