Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial (NCT06863129)
Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Randomized Controlled Trial
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to find out if removing and replacing part of the hip bone works better than using metal hardware to stabilize the bone in patients whose cancer has spread to the hip. The main questions are: 1. Does removing and replacing part of the bone work better than just stabilizing it with metal hardware? 2. Does removing and replacing the bone help reduce problems like cancer coming back or the metal hardware breaking? Researchers will compare two treatments: using metal rods and plates to stabilize the bone (internal fixation) versus removing part of the bone and possibly replacing the hip joint (resection and reconstruction) to see if the second option causes fewer problems. Participants will: * Be randomly assigned to one of two groups (internal fixation or resection and reconstruction). * Have one of the two surgeries based on which group they're in. * Go to follow-up appointments with the study doctor at 2 weeks, 6 weeks, 4 months, 6 months, 9 months, and 12 months after surgery.
Who can join: Review the eligibility criteria below.
Location: University of Colorado Hospital — Aurora, Colorado
Age range: 18 Years
🧪 Interventions in This Study
- Internal Fixation (PROCEDURE)
- Resection and reconstruction (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (13 Sites)
- University of Colorado Hospital — Aurora, Colorado
- Parkview Packnett Family Cancer Institute — Fort Wayne, Indiana
- University of Maryland Medical Center — Baltimore, Maryland
- Albany Medical Center — Albany, New York
- University of Cincinnati Medical Center — Cincinnati, Ohio
- Good Samaritan Regional Medical Center — Corvallis, Oregon
- Oregon Health and Science University Hospital — Portland, Oregon
- Medical University Graz — Graz,
- Hospital de Clínicas de Porto Alegre — Porto Alegre, Rio Grande do Sul
- Foothills Medical Centre — Calgary, Alberta
- Mount Sinai Hospital — Toronto, Ontario
- Hôpital Maisonneuve-Rosemont — Montreal, Quebec
- McGill University Health Centre — Montreal, Quebec
📞 Contact the Study Coordinator
Phone: (905) 521-2100
Email: viragoe@mcmaster.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Metastatic Bone Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.