🏛️ Verified NIH Record • Updated 2026-02-13
53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee (NCT06865079)
A Randomized, Double-blind, Placebo-controlled, 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Severe Tibio- Femoral Osteoarthritis of the Knee
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: OrthoTrophix, Inc
🩺 Plain-English Summary (8th-Grade Level)
53-Week Study Evaluating the Safety and Efficacy of Intra-articular (IA) Injections of TPX-100 vs Placebo in Subjects with Mild to Severe Tibio-Femoral Osteoarthritis of the Knee
Who can join: Review the eligibility criteria below.
Location: Elite Clinical Network — Scottsdale, Arizona
Age range: 50 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (33 Sites)
Showing the first 25 of 33 sites.
- Elite Clinical Network — Scottsdale, Arizona
- Noble Clinical Research — Tucson, Arizona
- Legent Orthopedic Hospital — Carrolton, California
- Medvin Clinical Research — Covina, California
- CORE Orthopaedic Medical Center — Encinitas, California
- Marvel Clinical Research (Elite Clinical Network) — Huntington Beach, California
- Medvin Clinical Research Center — Riverside, California
- Medvin Clinical Research Center — Tujunga, California
- Medvin Clinical Research Center — Whittier, California
- K2 Medical Research — Maitland, Florida
- Wellness Research Center — Miami, Florida
- Well Pharma Medical Research — Miami, Florida
- Las Mercedes Medical Research — Miami, Florida
- Drug Studies of America — Marietta, Georgia
- AMR Kansas City — Kansas City, Kansas
- University of Kansas Medical Center — Kansas City, Kansas
- AMR Lexington — Lexington, Kentucky
- Accurate Clinical Research Inc. — Lake Charles, Louisiana
- Mayo Clinic (Rochester) — Rochester, Minnesota
- Las Vegas Clinical Trials — North Las Vegas, Nevada
- Albuquerque Clinical Trials — Albuquerque, New Mexico
- Center for Clinical Research — Winston-Salem, North Carolina
- Hightower Clinical — Oklahoma City, Oklahoma
- University Orthopedics Center — Altoona, Pennsylvania
- University Orthopedics Center — State College, Pennsylvania
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Osteoarthritis (OA) of the Knee
- INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE — Larkspur, California
- Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride? — Sacramento, California
- The GORUN Study: Gradual Onset of RUNning and Knee Joint Health in Novice Runners — Vancouver, British Columbia
- Pharmacist-physiotherapist Collaborative Management for Early Knee Osteoarthritis — Sherwood Park, Alberta
- Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty — Grosse Pointe Farms, Michigan
Explore by condition: All Osteoarthritis (OA) of the Knee clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.