VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in Participants With Early Alzheimer's Disease (NCT06874621)
VY7523-102: A Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Multiple Ascending Intravenous Doses of VY7523 in Participants With Early Alzheimer's Disease
🩺 Plain-English Summary (8th-Grade Level)
This study is to be conducted in participants with early Alzheimer's Disease to test VY7523, a new drug being researched for treatment of Alzheimer's Disease. This study will look at how safe the drug is and how it works in the brain. It was first tested in normal, healthy participants who volunteered to participate. The study will look at three different dose levels, starting with the lowest dose first and moving to higher doses and more participants after safety has been reviewed by doctors and researchers. Some patients will receive drug while others will receive placebo. This will help to better compare how the drug works between participants receiving drug and placebo. The study will last up to 6 months for the lower dose groups and 12 months for the highest dose group.
Who can join: Review the eligibility criteria below.
Location: VYGR Site 840018 — Los Angeles, California
Age range: 50 Years to 90 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (23 Sites)
- VYGR Site 840018 — Los Angeles, California
- VYGR Site 840016 — Orange, California
- VYGR Site 840022 — San Francisco, California
- VYGR Site 840008 — Stamford, Connecticut
- VYGR Site 840005 — Delray Beach, Florida
- VYGR Site 840021 — Fort Myers, Florida
- VYGR Site 840010 — Lady Lake, Florida
- VYGR Site 840015 — Miami, Florida
- VYGR Site 840014 — Miami, Florida
- VYGR Site 840024 — Miami, Florida
- VYGR Site 840006 — Orlando, Florida
- VYGR Site 840003 — Stuart, Florida
- VYGR Site 840004 — The Villages, Florida
- VYGR Site 840002 — Wellington, Florida
- VYGR Site 840020 — Winter Park, Florida
- VYGR Site 840007 — Decatur, Georgia
- VYGR Site 840012 — Toms River, New Jersey
- VYGR Site 840009 — Matthews, North Carolina
- VYGR Site 840011 — Plymouth Meeting, Pennsylvania
- VYGR Site 124002 — Ottawa, Ontario
- VYGR Site 124001 — Toronto, Ontario
- VYGR Site 124003 — Montreal, Quebec
- VYGR Site 124004 — Montreal, Quebec
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Alzheimer's Disease (AD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.