Understanding and Treating Suicidal Ideation With Ketamine (NCT06891300)
Understanding and Treating Suicidal Ideation With Ketamine: A Diffusion Magnetic Resonance Imaging Study
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to treat active suicidal ideation in individuals with Major Depressive Disorder (MDD) using ketamine and to understand suicidal ideation by examining biological mechanisms using magnetic resonance imaging (MRI), and psychological mechanisms through validated clinical scales and qualitative interviews. The main questions it aims to answer are: 1. Will ketamine will reduce suicidal ideation in a significant proportion of study participants? 2. Will reduction in suicidal ideation will be accompanied by rapid changes in neuroimaging biomarkers? Participants will receive four intravenous (IV) ketamine infusions administered twice weekly for two weeks. Participants will undergo two identical MRI scans: 1) within 48 hours prior to starting ketamine treatment, and 2) 24 hours after the fourth ketamine infusion. Suicidal ideation and depressive symptoms will be assessed prior to each imaging session alongside additional self-report measures. Qualitative interviews will occur within 72 hours after the fourth ketamine treatment.
Who can join: Review the eligibility criteria below.
Location: Royal Ottawa Mental Health Centre — Ottawa, Ontario
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Royal Ottawa Mental Health Centre — Ottawa, Ontario
📞 Contact the Study Coordinator
Phone: (613) 722-6521
Email: suzannah.wojcik@theroyal.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Suicidal Ideation
- Dynamic Deconstructive Psychotherapy Versus Brief Intervention and Contact for Suicidal Adolescents and Young Adults — Syracuse, New York
- The Group Risk Reduction Intervention Therapy (GRRIT) Project — Portsmouth, Virginia
- A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior — Boston, Massachusetts
- Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial — Cleveland, Ohio
- Neural Correlates of Suicidal Behavior in Youth — Cleveland, Ohio
- Task-Shifting Adapted IPT-A for Youth Suicide Prevention — Chestnut Hill, Massachusetts
Explore by condition: All Suicidal Ideation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.