Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3 (NCT06891755)
🩺 Plain-English Summary (8th-Grade Level)
The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea due to hyperinflation despite optimal medical treatment. The Apreo BREATHE Airway Scaffold is a permanent implant designed to tent open native airways. The study will include up to 250 participants at up to 25 study centers located in the United States and Europe. Study subjects will be followed for 3 years. The main questions it aims to answer are: Is it safe? Does it work?
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 40 Years to 84 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (22 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- Banner Health — Gilbert, Arizona
- University of California at Davis — Sacramento, California
- Mayo Clinic — Jacksonville, Florida
- Orlando Health — Orlando, Florida
- University of Chicago — Chicago, Illinois
- OSF St Francis Medical Center — Peoria, Illinois
- University of Kansas Medical Center Research Institute — Kansas City, Kansas
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- Cleveland Clinic Foundation — Cleveland, Ohio
- The Ohio State University — Columbus, Ohio
- Clinical Research Associates of Central Pennsylvania — DuBois, Pennsylvania
- Temple University — Philadelphia, Pennsylvania
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
- Houston Methodist/Primary Critical Care — Houston, Texas
- Inova Health Care Services — Falls Church, Virginia
- Medical College of Wisconsin — Milwaukee, Wisconsin
- Karl Landsteiner Institute - Klink Floridsdorf — Vienna,
- University Medical Center Groningen — Groningen,
- St. Bartholomew's Hospital — London,
- Royal Brompton Hospital — London,
📞 Contact the Study Coordinator
Phone: (650) 326-2656
Email: cindy.holtz@apreohealth.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.