Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations (NCT06898138)
Acute Stimulation for the Modulation of Epileptic Events With a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
🩺 Plain-English Summary (8th-Grade Level)
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic — Rochester, Minnesota
Age range: 3 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Mayo Clinic — Rochester, Minnesota
- Baylor College of Medicine — Houston, Texas
📞 Contact the Study Coordinator
Phone: (507) 284-3134
Email: Ince.Nuri@mayo.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Epilepsy
- Neural Circulatory Control and SUDEP Risk. — Rochester, Minnesota
- BHV-7000 Responsive Neurostimulation System (RNS) Study — New Haven, Connecticut
- RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS — Stanford, California
- Acute Recording of Stereotyped High-Frequency Oscillations — Rochester, Minnesota
- Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy — Rochester, Minnesota
- Acoustic Stimulation for Seizure Suppression — New York, New York
Explore by condition: All Epilepsy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.