XL092 and Cemiplimab in BRAF WT Thyroid Cancer (NCT06902376)
NEO-COMBAT XL: Neoadjuvant and Maintenance XL092 and Cemiplimab in BRAF V600E-wildtype Anaplastic Thyroid Cancer: a Phase 1B Study
🩺 Plain-English Summary (8th-Grade Level)
This multicenter study examines the safety and feasibility of the combination of neoadjuvant XL092 and cemiplimab prior to surgical resection in participants with wild-type (WT) anaplastic thyroid cancer (ATC) that has a BRAF mutation (BRAF V600E).
Who can join: Review the eligibility criteria below.
Location: Dana Farber/Harvard Cancer Center — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Dana Farber/Harvard Cancer Center — Boston, Massachusetts
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina
📞 Contact the Study Coordinator
Phone: (919) 966-0808
Email: rose_hall@med.unc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Anaplastic Thyroid Cancer
- Trametinib in Combination With Paclitaxel in the Treatment of Anaplastic Thyroid Cancer — Basking Ridge, New Jersey
- Study of AIC100 CAR T Cells in Relapsed/Refractory Thyroid Cancer — Duarte, California
- Study of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid Cancer — Basking Ridge, New Jersey
- Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer — Houston, Texas
Explore by condition: All Anaplastic Thyroid Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.