A Study to Evaluate the Safety and Immunogenicity of the V3-region Directed Immunogens DV700P-RNA Followed by DV701B1.1-RNA in Adults Without HIV (NCT06919016)
A Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of the V3-region Directed Immunogens DV700P-RNA (Prime) Followed by DV701B1.1-RNA (Boost) in Adult Participants Without HIV
🩺 Plain-English Summary (8th-Grade Level)
This is a phase 1, first-in-human (FIH) trial for two vaccines, DV700P-RNA and DV701B1.1-RNA. This means it is the first time these study products are being tested in people. The purpose of this study is to see if the study products are safe, if people are able to take them without becoming too uncomfortable, and how a person's immune system responds to them (a person's immune system protects them from infections and disease). Forty-five volunteers without HIV and in overall good health, aged 18 to 55 years, will be enrolled and be in this study for about 16 months (about 12 visits), Study procedures will include blood draws, injections, and the collection of white blood cells and cells from their lymph nodes.
Who can join: Review the eligibility criteria below.
Location: University of Alabama Medical Center (Site ID: 31788) — Birmingham, Alabama
Age range: 18 Years to 55 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (8 Sites)
- University of Alabama Medical Center (Site ID: 31788) — Birmingham, Alabama
- The Hope Clinic of the Emory Vaccine Center CRS (Site ID: 31440) — Decatur, Georgia
- Brigham and Women's Hospital (Site ID: 30007) — Boston, Massachusetts
- Columbia P&S CRS (Site ID: 30329) — New York, New York
- University of Rochester Medical Center (Site ID: 31467) — Rochester, New York
- University of Pittsburgh (Site ID: 1001) — Pittsburgh, Pennsylvania
- Vanderbilt University Medical Center (Site ID: 30352) — Nashville, Tennessee
- Seattle Vaccine and Prevention CRS (Site ID: 30331) — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.