A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL) (NCT06943872)
A Phase 3 Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
🩺 Plain-English Summary (8th-Grade Level)
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
Who can join: Review the eligibility criteria below.
Location: Uci Health Laguna Hills — Laguna Hills, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (195 Sites)
Showing the first 25 of 195 sites.
- Uci Health Laguna Hills — Laguna Hills, California
- Chao Family Comprehensive Cancer Center — Orange, California
- Stanford Cancer Institute — Palo Alto, California
- Scripps Prebys Cancer Center — San Diego, California
- Rocky Mountain Cancer Centers (Williams) Usor — Aurora, Colorado
- Yale University Yale Cancer Center — New Haven, Connecticut
- Eastern Connecticut Hematology and Oncology — Norwich, Connecticut
- Cleveland Clinic Florida — Weston, Florida
- Northwestern University — Chicago, Illinois
- Illinois Cancer Specialists (Niles) Usor — Niles, Illinois
- University of Iowa Hospitals and Clinics — Iowa City, Iowa
- Mission Cancer and Blood — Waukee, Iowa
- University of Louisville, Brown Cancer Center — Louisville, Kentucky
- Mary Bird Perkins Cancer Center — Baton Rouge, Louisiana
- The University of Maryland Greenebaum Comprehensive Cancer Center — Baltimore, Maryland
- Beth Israel Deaconess Medical Center (Bidmc) — Boston, Massachusetts
- Dana Farber Cancer Institute — Boston, Massachusetts
- The Cancer and Hematology Centers — Grand Rapids, Michigan
- Mayo Clinic Rochester — Rochester, Minnesota
- University of Nebraska Medical Center — Omaha, Nebraska
- Sidney Kimmel Comprehensive Cancer Center Washington Twp — Sewell, New Jersey
- Christus St Vincent Regional Cancer Center — Santa Fe, New Mexico
- Memorial Sloan Kettering Cancer Center Mskcc — New York, New York
- Optum Medical Care, Pc — Westbury, New York
- University of North Carolina At Chapel Hill — Chapel Hill, North Carolina
📞 Contact the Study Coordinator
Phone: (877) 828-5568
Email: clinicaltrials@beonemed.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Chronic Lymphocytic Leukemia
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- Pirtobrutinib and Venetoclax With MRD Detection for Previously Untreated Chronic Lymphocytic Leukemia — Rochester, Minnesota
- A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) — Anchorage, Alaska
- Economic Analysis of Alliance A041202 CLL Study — Calgary, Alberta
- A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL — Chandler, Arizona
- Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL) — Phoenix, Arizona
Explore by condition: All Chronic Lymphocytic Leukemia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.