Vagal Stimulation Therapy and Preeclampsia (NCT06953115)
Vagal Autonomic Stimulation Physiotherapy (With Trigger Point Release) as an Adjunct to Personalized Antihypertensive Management of Gestational Hypertension Syndrome and Preeclampsia
🩺 Plain-English Summary (8th-Grade Level)
Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including neurological issues and reduced blood flow to the placenta. Preeclampsia is responsible for a significant number of maternal and perinatal deaths worldwide, with an estimated 14% of maternal mortality in Mexico linked to this condition. Recent research suggests that disruptions in the body's autonomic nervous system, specifically the balance between the sympathetic and parasympathetic systems, play a role in the development of preeclampsia. The vagus nerve, which is part of the parasympathetic system, has been shown to regulate inflammation and blood pressure. Stimulating this nerve through pharmacological, magnetic, electrical, or physical therapy techniques has shown promise in preclinical models for improving blood pressure control and reducing complications associated with preeclampsia. Trigger point release therapy modulates the nervous system by reducing sympathetic activity, promoting blood vessel relaxation, lowering heart rate, and enhancing circulation. When combined with standard antihypertensive treatment, this approach may offer additional benefits for blood pressure regulation. This study aims to evaluate the effects of vagal autonomic stimulation physiotherapy using trigger point release therapy as a complementary treatment for pregnant women with preeclampsia. Participants will be randomly assigned to receive either standard antihypertensive treatment with positional release therapy (control group) or the same treatment combined with vagal stimulation physiotherapy (intervention group). Researchers will assess the intervention's effectiveness in controlling blood pressure and improving overall maternal and fetal health outcomes. By investigating this non-invasive, drug-free approach, this study aims to offer new strategies for managing preeclampsia, potentially improving maternal and fetal health while reducing reliance on medication.
Who can join: Review the eligibility criteria below.
Location: Unidad de Investigación Biomédica 02, UMAE HE CMNO IMSS — Guadalajara, Jalisco
Age range: 18 Years
🧪 Interventions in This Study
- Vagal stimulation physiotherapy with trigger point release (OTHER)
- Positional Release Therapy (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- Unidad de Investigación Biomédica 02, UMAE HE CMNO IMSS — Guadalajara, Jalisco
- Hospital General de Zona 110, IMSS — Guadalajara, Jalisco
- Hospital General de Zona 46, IMSS — Guadalajara, Jalisco
- Hospital General de Zona 180, IMSS — Tlajomulco de Zúñiga, Jalisco
📞 Contact the Study Coordinator
Phone: (333) 668-3000
Email: luz.balderasp@imss.gob.mx
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Gestational Hypertension
- Postpartum CO Rehabilitation — Montreal, Quebec
- Angiogenic Factors in the Conservative Management of Gestational Hypertension — Panama City, Provincia de Panamá
- A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk Reduction in the Postpartum Period of Hypertensive Pregnancies (HP) — Ann Arbor, Michigan
- Digital Solutions to Reduce Maternal Morbidity and Mortality in Pregnant Refugee Women — New York, New York
Explore by condition: All Gestational Hypertension clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.