Project COMET: Massed Prolonged Exposure for PTSD and SUD (NCT06968832)
Project COMET: Hybrid Effectiveness-Implementation Trial of Massed PTSD Treatment in a Community Substance Use Program
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are: * Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)? * Does M-PE reduce the number of days participants use substances? * How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trauma TAU? * Researchers will compare M-PE to treatment as usual to see if M-PE leads to better mental health and substance use outcomes and lower dropout rates. Participants will: * Attend multiple therapy sessions per week (M-PE) or receive usual care * Complete assessments at baseline, during treatment, end-of-treatment, 1-month, 3-month, and 6-month follow-up * Share feedback through surveys and interviews about their experience in the program
Who can join: Review the eligibility criteria below.
Location: Gateway Community Services — Jacksonville, Florida
Age range: 18 Years
🧪 Interventions in This Study
- Massed Prolonged Exposure Therapy (M-PE) (BEHAVIORAL)
- Standard outpatient SUD care (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Gateway Community Services — Jacksonville, Florida
📞 Contact the Study Coordinator
Phone: (848) 445-0749
Email: denise.hien@smithers.rutgers.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Posttraumatic Stress Disorder (PTSD)
- Adaptation and Randomized Controlled Trial of Written Exposure Therapy for Adolescents — Charleston, South Carolina
- Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder — New York, New York
- Predictors & Mechanisms of Adolescent PTSD — Charleston, South Carolina
- EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder — Belmont, Massachusetts
- Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits) — Hamilton, Ontario
- Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD) — Charlestown, Massachusetts
Explore by condition: All Posttraumatic Stress Disorder (PTSD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.