Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study (NCT06972056)
A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study
🩺 Plain-English Summary (8th-Grade Level)
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
Who can join: Review the eligibility criteria below.
Location: Northern Arizona Healthcare — Flagstaff, Arizona
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (36 Sites)
Showing the first 25 of 36 sites.
- Northern Arizona Healthcare — Flagstaff, Arizona
- Mayo Clinic Arizona — Phoenix, Arizona
- Keck School of Medicine of USC — Los Angeles, California
- Clinical Research Institute — Los Angeles, California
- Desert Physicians Medical Group — Palm Springs, California
- The Neurology Group — Pomona, California
- University of Colorado Anschutz Medical Campus — Aurora, Colorado
- Memorial Healthcare — Hollywood, Florida
- Mayo Clinic Florida — Jacksonville, Florida
- Apple Med Research — Miami, Florida
- University of Miami — Miami, Florida
- Neuroscience Research Center — Overland Park, Kansas
- Clinical Trials of New England — Hyde Park, Massachusetts
- Mayo Clinic — Rochester, Minnesota
- Washington University St Louis — St Louis, Missouri
- Nebraska Medical Center — Omaha, Nebraska
- Advanced Research Institute Reno — Reno, Nevada
- JFK Neuroscience Institute — Edison, New Jersey
- Nuvance Health Institute — Kingston, New York
- Northwell Health — Manhasset, New York
- Mt Sinai Icahn School of Medicine — New York, New York
- Onsite Clinical Solutions Park Cedar Dr. — Charlotte, North Carolina
- Onsite Clinical Solutions Mecklenburg — Charlotte, North Carolina
- Onsite Clinical Solutions Ballantyne — Charlotte, North Carolina
- Onsite Clinical Solutions Salisbury — Salisbury, North Carolina
📞 Contact the Study Coordinator
Phone: (480) 342-2908
Email: ARZAPTTrial@mayo.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Migraine clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.