A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection (NCT06987318)
A Phase I Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the safety, tolerability, and efficacy of combination broadly neutralizing antibodies (bNAbs), to induce HIV-1 control during analytic treatment interruption (ATI).
Who can join: Review the eligibility criteria below.
Location: Alabama CRS — Birmingham, Alabama
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (13 Sites)
- Alabama CRS — Birmingham, Alabama
- UCSD Antiviral Research Center CRS — San Diego, California
- University of Colorado Hospital CRS — Aurora, Colorado
- The Ponce de Leon Center CRS — Atlanta, Georgia
- Northwestern University CRS — Chicago, Illinois
- Massachusetts General Hospital CRS (MGH CRS) — Boston, Massachusetts
- Chapel Hill CRS — Chapel Hill, North Carolina
- Ohio State University CRS — Columbus, Ohio
- Penn Therapeutics CRS — Philadelphia, Pennsylvania
- Houston Advancing Research Team CRS — Houston, Texas
- Instituto de Pesquisas em AIDS do Rio Grande do Sul - IPARGS CRS — Porto Alegre, Rio Grande do Sul
- Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS — Rio de Janeiro,
- Barranco CRS — Lima,
📞 Contact the Study Coordinator
Phone: (205) 934-6774
Email: heatherlogan@uabmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.