A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes (NCT06993792)
A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).
Who can join: Review the eligibility criteria below.
Location: Clinical Research Institute of Arizona (CRI) - Sun City West โ Sun City West, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (80 Sites)
Showing the first 25 of 80 sites.
- Clinical Research Institute of Arizona (CRI) - Sun City West โ Sun City West, Arizona
- Novak Clinical Research - Tucson - North La Cholla Boulevard โ Tucson, Arizona
- Norcal Endocrinology & Internal Medicine โ San Ramon, California
- Southern California Clinical Research โ Santa Ana, California
- Care Access - Thousand Oaks โ Thousand Oaks, California
- Accel Research Sites - DeLand Clinical Research Unit โ DeLand, Florida
- Innovation Medical Research Center - Fort Lauderdale โ Fort Lauderdale, Florida
- Indago Research & Health Center, Inc โ Hialeah, Florida
- Encore Medical Research โ Hollywood, Florida
- West Orange Endocrinology P.A. โ Ocoee, Florida
- Care Access - Tampa โ Tampa, Florida
- Conquest Research โ Winter Park, Florida
- Accel Research Sites - NeuroStudies Clinical Research Unit โ Decatur, Georgia
- Care Access - Decatur โ Decatur, Georgia
- Javara - Privia Medical Group Georgia - Savannah โ Savannah, Georgia
- North Georgia Clinical Research โ Woodstock, Georgia
- Solaris Clinical Research โ Meridian, Idaho
- Care Access - New Iberia โ New Iberia, Louisiana
- Endocrine and Metabolic Consultants โ Rockville, Maryland
- Javara - Privia Medical Group - Silver Spring โ Silver Spring, Maryland
- Great Lakes Research Group, Inc. โ Bay City, Michigan
- Boeson Research MSO โ Missoula, Montana
- Javara - Nevada Health Centers - Carson City โ Carson City, Nevada
- The Machuca Foundation โ Las Vegas, Nevada
- University of North Carolina Medical Center โ Chapel Hill, North Carolina
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Obesity
- Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools โ Tampa, Florida
- SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity โ Tucson, Arizona
- Piloting a Patient Navigator Program for Weight Loss โ Philadelphia, Pennsylvania
- Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) โ Mesa, Arizona
- Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects โ Orlando, Florida
- Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans โ Pittsburgh, Pennsylvania
Explore by condition: All Obesity clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.