๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-30

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes (NCT06993792)

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Eli Lilly and Company

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).

Who can join: Review the eligibility criteria below.

Location: Clinical Research Institute of Arizona (CRI) - Sun City West โ€” Sun City West, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (80 Sites)

Showing the first 25 of 80 sites.

  • Clinical Research Institute of Arizona (CRI) - Sun City West โ€” Sun City West, Arizona
  • Novak Clinical Research - Tucson - North La Cholla Boulevard โ€” Tucson, Arizona
  • Norcal Endocrinology & Internal Medicine โ€” San Ramon, California
  • Southern California Clinical Research โ€” Santa Ana, California
  • Care Access - Thousand Oaks โ€” Thousand Oaks, California
  • Accel Research Sites - DeLand Clinical Research Unit โ€” DeLand, Florida
  • Innovation Medical Research Center - Fort Lauderdale โ€” Fort Lauderdale, Florida
  • Indago Research & Health Center, Inc โ€” Hialeah, Florida
  • Encore Medical Research โ€” Hollywood, Florida
  • West Orange Endocrinology P.A. โ€” Ocoee, Florida
  • Care Access - Tampa โ€” Tampa, Florida
  • Conquest Research โ€” Winter Park, Florida
  • Accel Research Sites - NeuroStudies Clinical Research Unit โ€” Decatur, Georgia
  • Care Access - Decatur โ€” Decatur, Georgia
  • Javara - Privia Medical Group Georgia - Savannah โ€” Savannah, Georgia
  • North Georgia Clinical Research โ€” Woodstock, Georgia
  • Solaris Clinical Research โ€” Meridian, Idaho
  • Care Access - New Iberia โ€” New Iberia, Louisiana
  • Endocrine and Metabolic Consultants โ€” Rockville, Maryland
  • Javara - Privia Medical Group - Silver Spring โ€” Silver Spring, Maryland
  • Great Lakes Research Group, Inc. โ€” Bay City, Michigan
  • Boeson Research MSO โ€” Missoula, Montana
  • Javara - Nevada Health Centers - Carson City โ€” Carson City, Nevada
  • The Machuca Foundation โ€” Las Vegas, Nevada
  • University of North Carolina Medical Center โ€” Chapel Hill, North Carolina

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Obesity clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—