The Vanguard Study: Testing a New Way to Screen for Cancer (NCT06995898)
🩺 Plain-English Summary (8th-Grade Level)
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers in the blood in order to screen for multiple cancers simultaneously. There is a need to understand how MCDs may work as cancer screening tools. The goal of cancer screening is to reduce the burden of cancer by identifying cancers before they show symptoms or signs, when treatment is likely to be most effective. In this study, adults aged 45-75 without cancer will be randomly assigned to one of 3 groups: 2 separate MCD test groups or a control group. These two MCD tests will not be compared to each other but will be compared to cancers detected in the control group. This study will provide early information on how well MCD tests perform as cancer screening tools. It will also help researchers understand how patients and their doctors make decisions about their care when the MCD test result comes back as normal (negative) or abnormal (positive).
Who can join: Review the eligibility criteria below.
Location: Kaiser Permanente-Division of Research — Pleasanton, California
Age range: 45 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (41 Sites)
Showing the first 25 of 41 sites.
- Kaiser Permanente-Division of Research — Pleasanton, California
- Keefe Memorial Hospital — Cheyenne Wells, Colorado
- Kaiser Permanente-Franklin — Denver, Colorado
- Poudre Valley Hospital — Fort Collins, Colorado
- Cancer Care and Hematology-Fort Collins — Fort Collins, Colorado
- UCHealth Greeley Hospital — Greeley, Colorado
- Kaiser Permanente-Rock Creek — Lafayette, Colorado
- Kaiser Permanente-Lone Tree — Lone Tree, Colorado
- Medical Center of the Rockies — Loveland, Colorado
- Kaiser Permanente Moanalua Medical Center — Honolulu, Hawaii
- Walter Reed National Military Medical Center — Bethesda, Maryland
- Henry Ford Cancer Institute-Downriver — Brownstown, Michigan
- Henry Ford Health Center - Brownstown — Brownstown, Michigan
- Henry Ford Health Center - Chesterfield — Chesterfield, Michigan
- Henry Ford Macomb Hospital-Clinton Township — Clinton Township, Michigan
- Henry Ford Medical Center-Fairlane — Dearborn, Michigan
- Henry Ford Hospital — Detroit, Michigan
- Henry Ford Medical Center - Detroit Northwest — Detroit, Michigan
- Henry Ford Medical Center-Cottage — Grosse Pointe Farms, Michigan
- Henry Ford Medical Center - Livonia — Livonia, Michigan
- Henry Ford Medical Center-Columbus — Novi, Michigan
- Henry Ford Medical Center - Plymouth — Plymouth, Michigan
- Henry Ford Medical Center - Royal Oak — Royal Oak, Michigan
- Henry Ford Medical Center — Sterling Heights, Michigan
- Henry Ford Medical Center - Troy — Troy, Michigan
📞 Contact the Study Coordinator
Phone: (510) 891-3400
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.