Who is eligible for clinical trial NCT07000136?

Participants must meet protocol criteria for Heterozygous Familial Hypercholesterolaemia. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07000136 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-07-15

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH (NCT07000136)

A Phase III, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Effect of AZD0780 on Low-Density Lipoprotein Cholesterol in Patients With Heterozygous Familial Hypercholesterolaemia

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This is a study to evaluate the efficacy and safety of AZD0780 in adults with HeFH and elevated LDL-C, either with clinical ASCVD and LDL-C levels of 55 mg/dL or higher or without clinical ASCVD and LDL-C levels of 70 mg/dL or higher. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood. Placebo will be used for comparison, and neither the participants nor the Investigators will know who is receiving the AZD0780 medication and who is receiving the placebo until the end of study. The total length of the study for an individual participant will be up to approximately 56 weeks, including a screening period of up to 14 days, treatment with AZD0780 or placebo for 52 weeks, and a safety follow-up period of 10 days.

Who can join: Review the eligibility criteria below.

Location: Research Site — Garden Grove, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (133 Sites)

Showing the first 25 of 133 sites.

Research Site — Garden Grove, California
Research Site — San Diego, California
Research Site — Miami Lakes, Florida
Research Site — Orlando, Florida
Research Site — Peachtree Corners, Georgia
Research Site — Chicago, Illinois
Research Site — Hammond, Louisiana
Research Site — Las Vegas, Nevada
Research Site — New York, New York
Research Site — Morganton, North Carolina
Research Site — Cincinnati, Ohio
Research Site — Lima, Ohio
Research Site — Chattanooga, Tennessee
Research Site — Houston, Texas
Research Site — Humble, Texas
Research Site — Kingwood, Texas
Research Site — McAllen, Texas
Research Site — Mesquite, Texas
Research Site — Redmond, Washington
Research Site — CABA,
Research Site — Ciudad Autonoma de Bs As,
Research Site — Ciudad de Buenos Aires,
Research Site — Ciudad de Buenos Aires,
Research Site — Mar del Plata,
Research Site — Rosario,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Heterozygous Familial Hypercholesterolaemia clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗