Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia (NCT07033481)
A Phase 2a Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients With Primary Progressive Aphasia (PPA)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this exploratory study is to evaluate the effect of neflamapimod in participants with nonfluent variant primary progressive aphasia (nfvPPA). We aim to evaluate the safety, pharmacokinetics and clinical effects of neflamapimod of participants with nfvPPA.
Who can join: Review the eligibility criteria below.
Location: Northwestern Memorial Hospital — Chicago, Illinois
Age range: 40 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (7 Sites)
- Northwestern Memorial Hospital — Chicago, Illinois
- Mayo Clinic — Rochester, Minnesota
- Columbia University — New York, New York
- The Ohio State University — Columbus, Ohio
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania
- Windsor Research Unit, Fulbourn Hospital — Cambridge,
- Clinical Ageing Research Unit, Campus for Ageing and Vitality, Biomedical Research Building — Newcastle upon Tyne,
📞 Contact the Study Coordinator
Phone: (855) 692-6482
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Nonfluent Variant Primary Progressive Aphasia (nfvPPA) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.