Who is eligible for clinical trial NCT07037771?

Participants must meet protocol criteria for Homozygous Familial Hypercholesterolemia. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07037771 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-10

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE) (NCT07037771)

Phase 3 Study to Evaluate the Efficacy and Safety of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Arrowhead Pharmaceuticals

🩺 Plain-English Summary (8th-Grade Level)

This multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of zodasiran subcutaneous (SC) injection in subjects 12 years of age and older with genetically or clinically diagnosed Homozygous familial hypercholesterolemia (HoFH). After completion of the double blind (DB) treatment period subjects will be eligible to continue in the optional open-label extension (OLE) period of the study. All placebo subjects who opt to continue will transition to active drug during the OLE Period.

Who can join: Review the eligibility criteria below.

Location: Research Site 7 — Park Ridge, Illinois

Age range: 12 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (43 Sites)

Showing the first 25 of 43 sites.

Research Site 7 — Park Ridge, Illinois
Research Site 2 — New York, New York
Research Site 1 — Cincinnati, Ohio
Research Site 14 — Pittsburgh, Pennsylvania
Research Site 13 — Camperdown, New South Wales
Research Site 9 — Saint Leonards, New South Wales
Research Site 21 — Heidelberg, Victoria
Research Site 3 — Nedlands, Western Australia
Research Site 40 — Innsbruck,
Research Site 39 — Linz,
Research Site 42 — Vienna,
Research Site 37 — Vienna,
Research Site 33 — La Louvière,
Research Site 34 — Leuven,
Research Site 24 — Cerqueira César, São Paulo
Research Site 5 — Vancouver, British Columbia
Research Site 6 — Chicoutimi, Quebec
Research Site 4 — Québec,
Research Site 30 — Hradec Králové,
Research Site 23 — Paris,
Research Site 17 — Tbilisi,
Research Site 18 — Tbilisi,
Research Site 19 — Tbilisi,
Research Site 35 — Berlin,
Research Site 10 — Jerusalem,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Homozygous Familial Hypercholesterolemia

The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository — New York, New York
HoFH, the International Clinical Collaborators Registry — Philadelphia, Pennsylvania

Explore by condition: All Homozygous Familial Hypercholesterolemia clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗