AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001) (NCT07038343)
A Phase 1/2, First-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.
Who can join: Review the eligibility criteria below.
Location: Avenzo Therapeutics Recruiting Site — Gilbert, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- Avenzo Therapeutics Recruiting Site — Gilbert, Arizona
- Avenzo Therapeutics Recruiting Site — Los Angeles, California
- Avenzo Therapeutics Recruiting Site — Santa Monica, California
- Avenzo Therapeutics Recruiting Site — Denver, Colorado
- Avenzo Therapeutics Recruiting Site — New Haven, Connecticut
- Avenzo Therapeutics Recruiting Site — Washington D.C., District of Columbia
- Avenzo Therapeutics Recruiting Site — Orlando, Florida
- Avenzo Therapeutics Recruiting Site — Sarasota, Florida
- Avenzo Therapeutics Recruiting Site — Tampa, Florida
- Avenzo Therapeutics Recruiting Site — Atlanta, Georgia
- Avenzo Therapeutics Recruiting Site — Boston, Massachusetts
- Avenzo Therapeutics Recruiting Site — New York, New York
- Avenzo Therapeutics Recruiting Site — Philadelphia, Pennsylvania
- Avenzo Therapeutics Recruiting Site — Dallas, Texas
- Avenzo Therapeutics Recruiting Site — Houston, Texas
- Avenzo Therapeutics Recruiting Site — San Antonio, Texas
- Avenzo Therapeutics Recruiting Site — West Valley City, Utah
- Avenzo Therapeutics Recruiting Site — Fairfax, Virginia
- Avenzo Therapeutics Recruiting Site — Seattle, Washington
📞 Contact the Study Coordinator
Phone: (858) 239-2944
Email: ClinicalTrials@avenzotx.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Metronomic Gemcitabine, Mitomycin C, and Thalidomide for Advanced Solid Tumors — Santa Monica, California
- BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001) — San Francisco, California
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.