TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (NCT07052903)
TRITON-CM: A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Transthyretin-Mediated Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life
Who can join: Review the eligibility criteria below.
Location: Clinical Trial Site — La Jolla, California
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (251 Sites)
Showing the first 25 of 251 sites.
- Clinical Trial Site — La Jolla, California
- Clinical Trial Site — Laguna Hills, California
- Clinical Trial Site — Stanford, California
- Clinical Trial Site — Norwich, Connecticut
- Clinical Trial Site — Washington D.C., District of Columbia
- Clinical Trial Site — Brandon, Florida
- Clinical Trial Site — Miami, Florida
- Clinical Trial Site — Atlanta, Georgia
- Clinical Trial Site — Gainesville, Georgia
- Clinical Trial Site — Tucker, Georgia
- Clinical Trial Site — Chicago, Illinois
- Clinical Trial Site — Evanston, Illinois
- Clinical Trial Site — Indianapolis, Indiana
- Clinical Trial Site — Indianapolis, Indiana
- Clinical Trial Site — Kansas City, Kansas
- Clinical Trial Site — Baltimore, Maryland
- Clinical Trial Site — Boston, Massachusetts
- Clinical Trial Site — Boston, Massachusetts
- Clinical Trial Site — Detroit, Michigan
- Clinical Trial Site — Rochester, Minnesota
- Clinical Trial Site — St Louis, Missouri
- Clinical Trial Site — Manhasset, New York
- Clinical Trial Site — New York, New York
- Clinical Trial Site — New York, New York
- Clinical Trial Site — New York, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.