SGLT2i in Kidney Stones (NCT07055282)
SGLT2i in Calcium Kidney Stones
🩺 Plain-English Summary (8th-Grade Level)
This study is looking at whether empagliflozin, a medication typically used for diabetes and heart conditions, may affect factors that contribute to kidney stone formation. The research focuses on people who have had calcium-based kidney stones, i.e. calcium oxalate or calcium phosphate stones. Previous studies in those without kidney stones found that empagliflozin increased urinary citrate levels without raising urine pH. The investigators are testing whether similar effects occur in people with a history of kidney stones. Participants will take empagliflozin daily for 4 weeks. The investigators will collect 24-hour urine samples before and after treatment to measure various factors that influence stone formation, including citrate levels, pH, and calculated stone formation risk. The investigators will enroll 32 participants: 16 with a history of calcium oxalate stones and 16 with calcium phosphate stones. Results from this study may inform future larger clinical trials investigating empagliflozin as a kidney stone prevention strategy.
Who can join: Review the eligibility criteria below.
Location: University of Chicago — Chicago, Illinois
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Chicago — Chicago, Illinois
📞 Contact the Study Coordinator
Phone: (773) 702-1000
Email: mprocha2@medicine.bsd.uchicago.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Kidney Stones
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- Feasibility of Radiation-Free Percutaneus Nephrolithotomy for Kidney Stones — San Diego, California
- FANS vs CVAC for Medium to Large Stones — Columbus, Ohio
- DISON I - Directly Integrated Suction and Optics System for the Treatment of Nephrolithiasis — Buenos Aires,
- The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults — Chicago, Illinois
- Pilot Study of Patient Navigation for Kidney Stone Patients After ED Visits — San Francisco, California
Explore by condition: All Kidney Stones clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.