A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30) (NCT07076121)
A Randomized, Phase 2/3 Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma Harboring Homozygous MTAP Deletion
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess the safety and efficacy of Navlimetostat (BMS-986504), a selective, MTA-cooperative PRMT5 inhibitor, in combination with Nab-paclitaxel/Gemcitabine (nab-p/gem) versus placebo in combination with nab-p/gem, in participants with untreated metastatic Pancreatic Ductal Adenocarcinoma (PDAC) with homozygous methylthioadenosine phosphorylase (MTAP) deletion.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic in Arizona - Phoenix โ Phoenix, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (269 Sites)
Showing the first 25 of 269 sites.
- Mayo Clinic in Arizona - Phoenix โ Phoenix, Arizona
- Local Institution - 0365 โ Tucson, Arizona
- Highlands Oncology Group โ Springdale, Arkansas
- Scripps Green Hospital โ La Jolla, California
- Local Institution - 0157 โ San Francisco, California
- Baptist MD Anderson Cancer Center โ Jacksonville, Florida
- Mayo Clinic in Florida โ Jacksonville, Florida
- Winship Cancer Institute, Emory University โ Atlanta, Georgia
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital โ Marietta, Georgia
- St. Luke's Cancer Institute: Boise โ Boise, Idaho
- Local Institution - 0168 โ Chicago, Illinois
- Local Institution - 0125 โ Westwood, Kansas
- Local Institution - 0370 โ Louisville, Kentucky
- Local Institution - 0371 โ Baltimore, Maryland
- Johns Hopkins Hospital โ Baltimore, Maryland
- Local Institution - 0120 โ Boston, Massachusetts
- Brigitte Harris Cancer Pavilion โ Detroit, Michigan
- The Cancer & Hematology Centers โ Grand Rapids, Michigan
- Mayo Clinic in Rochester, Minnesota โ Rochester, Minnesota
- University Of Nebraska Medical Center โ Omaha, Nebraska
- Roswell Park Cancer Institute โ Buffalo, New York
- Northwell Health/ RJ Zuckerberg Cancer Center โ Lake Success, New York
- Laura and Isaac Perlmutter Cancer Center at NYU Langone โ Mineola, New York
- NYU Winthrop Hospital โ Mineola, New York
- Icahn School of Medicine at Mount Sinai โ New York, New York
๐ Contact the Study Coordinator
Phone: (800) 664-4580
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Pancreatic Ductal Adenocarcinoma
- A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma โ Rochester, New York
- Enfortumab Vedotin in Previously Treated Locally Advanced or Metastatic Pancreatic Cancer (EPIC) โ Kansas City, Kansas
- Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer โ Durham, North Carolina
- Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer โ Washington D.C., District of Columbia
- A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma โ Philadelphia, Pennsylvania
- A Study to Evaluate ATP150/ATP152/ATP162, VSV-GP154 and Ezabenlimab in Patients With Pancreatic Ductal Adenocarcinoma โ Los Angeles, California
Explore by condition: All Pancreatic Ductal Adenocarcinoma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.