๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-02

A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30) (NCT07076121)

A Randomized, Phase 2/3 Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma Harboring Homozygous MTAP Deletion

๐Ÿ”ต Active, Not Recruiting Phase2 / Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Bristol-Myers Squibb

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to assess the safety and efficacy of Navlimetostat (BMS-986504), a selective, MTA-cooperative PRMT5 inhibitor, in combination with Nab-paclitaxel/Gemcitabine (nab-p/gem) versus placebo in combination with nab-p/gem, in participants with untreated metastatic Pancreatic Ductal Adenocarcinoma (PDAC) with homozygous methylthioadenosine phosphorylase (MTAP) deletion.

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic in Arizona - Phoenix โ€” Phoenix, Arizona

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (269 Sites)

Showing the first 25 of 269 sites.

  • Mayo Clinic in Arizona - Phoenix โ€” Phoenix, Arizona
  • Local Institution - 0365 โ€” Tucson, Arizona
  • Highlands Oncology Group โ€” Springdale, Arkansas
  • Scripps Green Hospital โ€” La Jolla, California
  • Local Institution - 0157 โ€” San Francisco, California
  • Baptist MD Anderson Cancer Center โ€” Jacksonville, Florida
  • Mayo Clinic in Florida โ€” Jacksonville, Florida
  • Winship Cancer Institute, Emory University โ€” Atlanta, Georgia
  • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital โ€” Marietta, Georgia
  • St. Luke's Cancer Institute: Boise โ€” Boise, Idaho
  • Local Institution - 0168 โ€” Chicago, Illinois
  • Local Institution - 0125 โ€” Westwood, Kansas
  • Local Institution - 0370 โ€” Louisville, Kentucky
  • Local Institution - 0371 โ€” Baltimore, Maryland
  • Johns Hopkins Hospital โ€” Baltimore, Maryland
  • Local Institution - 0120 โ€” Boston, Massachusetts
  • Brigitte Harris Cancer Pavilion โ€” Detroit, Michigan
  • The Cancer & Hematology Centers โ€” Grand Rapids, Michigan
  • Mayo Clinic in Rochester, Minnesota โ€” Rochester, Minnesota
  • University Of Nebraska Medical Center โ€” Omaha, Nebraska
  • Roswell Park Cancer Institute โ€” Buffalo, New York
  • Northwell Health/ RJ Zuckerberg Cancer Center โ€” Lake Success, New York
  • Laura and Isaac Perlmutter Cancer Center at NYU Langone โ€” Mineola, New York
  • NYU Winthrop Hospital โ€” Mineola, New York
  • Icahn School of Medicine at Mount Sinai โ€” New York, New York

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 664-4580

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—