Dehydration, Rehydration, and Impact on Physiology (NCT07084675)
Impact of Mild Dehydration and Subsequent Rehydration on Cellular Stress and Physiological Performance
🩺 Plain-English Summary (8th-Grade Level)
Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65. Aim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs. Aim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance. Participant will: complete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol. attend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyration protocol) Day 4: Post-dehydration testing (after the dehydration protocol) Day 5: Post-rehydration testing (after the rehydration protocol)
Who can join: Review the eligibility criteria below.
Location: Texas Tech University — Lubbock, Texas
Age range: 45 Years to 65 Years
🧪 Interventions in This Study
- Hydration-Dehydration-Rehydration Protocol (HDR) (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Texas Tech University — Lubbock, Texas
📞 Contact the Study Coordinator
Phone: (806) 834-0827
Email: huiying.luk@ttu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aging
- A Pilot Study on Reverse Aging (The REVERSE Study) — Cincinnati, Ohio
- Feasibility of Home-based tES for Older Adults at Risk of Falling — Roslindale, Massachusetts
- Heat, Microvascular Function and Aging — Milwaukee, Wisconsin
- Protein Quantity and Quality in Older Subjects — Hamilton, Ontario
- Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse — Salt Lake City, Utah
- Effect of a Daily Supplement on Plasma PAI-1 Levels — Los Angeles, California
Explore by condition: All Aging clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.