Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM (NCT07084896)
A Phase I/II, Randomized, Open-label Platform Study Utilizing a Master Protocol to Study Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Anti-Cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)-DREAMM5 - Sub-study 3 - Belantamab Mafodotin and Nirogacestat in Combination
🩺 Plain-English Summary (8th-Grade Level)
The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with nirogacestat and to establish the recommended Phase 2 dose for combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. This study is a sub study of the Master protocol (NCT04126200).
Who can join: Review the eligibility criteria below.
Location: 238995 — Atlanta, Georgia
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (29 Sites)
Showing the first 25 of 29 sites.
- 238995 — Atlanta, Georgia
- 240593 — Boston, Massachusetts
- 251164 — Grand Rapids, Michigan
- 239015 — Madison, Wisconsin
- GSK Investigational Site — Fitzroy, Victoria
- GSK Investigational Site — Vancouver, British Columbia
- GSK Investigational Site — Halifax, Nova Scotia
- GSK Investigational Site — Lille,
- GSK Investigational Site — Villejuif,
- GSK Investigational Site — Frankfurt,
- GSK Investigational Site — Kiel,
- GSK Investigational Site — Leipzig,
- GSK Investigational Site — Athens,
- GSK Investigational Site — Utrecht,
- GSK Investigational Site — Oslo,
- GSK Investigational Site — Katowice,
- GSK Investigational Site — Lodz,
- GSK Investigational Site — Lublin,
- GSK Investigational Site — Moscow,
- GSK Investigational Site — Incheon,
- GSK Investigational Site — Seoul,
- GSK Investigational Site — Seoul,
- GSK Investigational Site — Ulsan,
- GSK Investigational Site — Badalona,
- GSK Investigational Site — Madrid,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant — Tampa, Florida
- MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb — Beverly Hills, California
- A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma — Phoenix, Arizona
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.