Efficacy and Safety of NVX-CoV2705 (NCT07086222)
A Phase 4, Randomized, Double-Blind, Placebo-Controlled, Post-Marketing Study to Evaluate the Efficacy and Safety of an Omicron JN.1 Subvariant SARS-CoV-2 rS Vaccine Adjuvanted With Matrix-M® in Adults 50 to < 65 Years of Age Without High Risk Conditions for Severe COVID-19
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 4, post-market US study, evaluating the efficacy and safety of a single dose of the NVX-CoV2705 Omicron JN.1 COVID-19 vaccine. Approximately 6,500 healthy adults aged 50 to under 65 will be randomized to receive either the vaccine or a placebo, with follow-up for 180 days.
Who can join: Review the eligibility criteria below.
Location: North Alabama Research Center — Athens, Alabama
Age range: 50 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (99 Sites)
Showing the first 25 of 99 sites.
- North Alabama Research Center — Athens, Alabama
- TrialMed - Birmingham — Birmingham, Alabama
- Hawthorne Health - Gadsden — Gadsden, Alabama
- TrialdMed - Huntsville — Huntsville, Alabama
- AMR Mobile — Mobile, Alabama
- Headlands Research Scottsdale — Scottsdale, Arizona
- Orange Grove Family Practice — Tucson, Arizona
- 310 Clinical Research — Inglewood, California
- Velocity Clinical Research - San Diego — La Mesa, California
- Profound Research LLC at Seaside Medical Group — Oceanside, California
- California Research Foundation — San Diego, California
- Bayview Research Group, LLC — Valley Village, California
- Diablo Clinical Research, Inc. — Walnut Creek, California
- Alliance Clinical - West Hills — West Hills, California
- Lynn Institute of Denver — Aurora, Colorado
- Paradigm Clinical Research Centers, LLC — Wheat Ridge, Colorado
- Clinical Research Consulting, LLC — Milford, Connecticut
- SIMED Health, LLC / SIMED Research — Gainesville, Florida
- Indago Research and Health Center, Inc. — Hialeah, Florida
- Health Awareness, LLC — Jupiter, Florida
- TrialMed - Melbourne — Melbourne, Florida
- Acevedo Clinical Research Associates — Miami, Florida
- Research Institute Of South Florida, Inc. — Miami, Florida
- MOORE Clinical Research — Tampa, Florida
- TrialMed - The Villages — The Villages, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.